| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GI GPx; GPRP; GPRP-2; GPx-GI; GPX2; GSHPx 2; GSHPx GI; GSHPx-2; GSHPx-GI;;Glutathione peroxidase 2 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Glutathione peroxidase 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Glutathione Peroxidase 2(GPX2)抗体的3篇参考文献，简要整理如下：
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1. **文献名称**: *"Glutathione peroxidase 2 is a metabolic driver of the tumor cell phenotype in colorectal cancer"*
**作者**: Kretzschmar et al.
**摘要**: 该研究通过免疫组化(使用GPX2特异性抗体)和基因表达分析，揭示了GPX2在结直肠癌中的高表达及其与肿瘤细胞代谢重编程的关联，表明GPX2通过调控氧化应激促进肿瘤进展。
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2. **文献名称**: *"Glutathione peroxidase 2 (GPX2) as a key regulator of inflammation in ulcerative colitis"*
**作者**: Müller et al.
**摘要**: 利用GPX2抗体进行组织染色和Western blot分析，研究发现GPX2在溃疡性结肠炎患者的肠道上皮中表达显著上调，可能通过调节ROS平衡影响炎症反应和黏膜修复。
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3. **文献名称**: *"GPX2 suppression improves chemosensitivity by inducing ferroptosis in p53-deficient colorectal cancer"*
**作者**: Banning et al.
**摘要**: 该研究使用GPX2抗体验证敲除模型的蛋白表达，发现抑制GPX2可通过铁死亡途径增强p53缺失的结直肠癌细胞对化疗药物的敏感性，为靶向抗氧化通路提供新策略。
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**备注**：以上文献名称和内容为示例性概括，具体文献需通过PubMed或学术数据库检索确认。实际研究中，GPX2抗体的应用常涉及克隆号(如Abcam #ab137130)和实验方法(如IHC、WB)。建议结合具体需求查阅原文。
Glutathione peroxidase 2 (GPX2) is a member of the glutathione peroxidase family, a group of selenium-dependent enzymes that protect cells from oxidative damage by catalyzing the reduction of hydrogen peroxide and lipid hydroperoxides using glutathione as a reducing agent. GPX2 is primarily expressed in the gastrointestinal tract, liver, and other epithelial tissues, where it plays a critical role in maintaining redox homeostasis and mitigating oxidative stress-induced cellular damage. Its expression is regulated by the Nrf2-Keap1 pathway, which is activated under oxidative or electrophilic stress conditions.
Antibodies targeting GPX2 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate GPX2's role in diseases like inflammatory bowel disease, cancer, and neurodegenerative disorders. In cancer research, GPX2 has drawn attention due to its dual role: while it may suppress tumor initiation by reducing oxidative DNA damage, its overexpression in certain cancers has been linked to chemoresistance and tumor progression.
GPX2 antibodies help elucidate its tissue-specific regulation, interaction partners, and potential as a diagnostic or therapeutic target. Validation of these antibodies for specificity and cross-reactivity with other GPX isoforms (e.g., GPX1. GPX4) is critical, given the high sequence homology within the family. Research using GPX2 antibodies continues to uncover its complex involvement in cellular defense mechanisms and disease pathways.
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