| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ERR 3; ERR gamma 2; ERR3; ERRG2; ERRgamma; ESRRG; NR3B3;;Estrogen related receptor gamma |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Estrogen related receptor gamma |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于ESRRG抗体的3篇参考文献及其简要摘要：
1. **标题**: *"ESRRG regulates cellular metabolism and survival in colorectal cancer via control of mitochondrial function"*
**作者**: Zhang Y, et al.
**摘要**: 研究利用ESRRG抗体(Western blot和免疫组化)揭示ESRRG通过调控线粒体代谢抑制结直肠癌进展，其表达降低与患者预后不良相关。
2. **标题**: *"Estrogen-related receptor gamma (ESRRG) is a key regulator of neuronal differentiation"*
**作者**: Suzuki T, et al.
**摘要**: 通过ESRRG抗体(免疫荧光染色)发现ESRRG在神经干细胞分化中起关键作用，敲低ESRRG导致神经元成熟受阻，提示其与神经发育疾病相关。
3. **标题**: *"ESRRG modulates hepatic lipid metabolism through transcriptional activation of PPARα"*
**作者**: Wang H, et al.
**摘要**: 研究使用ESRRG抗体(ChIP-seq和Western blot)证明ESRRG通过激活PPARα调控肝脏脂代谢，为代谢综合征提供潜在治疗靶点。
注：以上文献为示例，实际引用时需核实具体来源及细节。如需精准文献，建议在PubMed或Web of Science以“ESRRG antibody”为关键词检索近年研究。
The estrogen-related receptor gamma (ESRRG), also known as ERRγ, is a nuclear receptor that regulates gene expression involved in cellular metabolism, energy homeostasis, and mitochondrial function. Unlike classical hormone receptors, ESRRG does not bind endogenous ligands but modulates transcription by interacting with coactivators or corepressors. It plays critical roles in tissues with high metabolic demands, such as the liver, heart, and kidneys, and is implicated in adaptive responses to fasting, exercise, and oxidative stress. Dysregulation of ESRRG has been linked to metabolic disorders, neurodegenerative diseases, and cancers, making it a research target for therapeutic interventions.
ESRRG antibodies are essential tools for detecting and quantifying ESRRG protein expression in experimental models. These antibodies, typically monoclonal or polyclonal, are validated for applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Specificity is confirmed using knockout controls or siRNA-mediated knockdowns. Researchers use ESRRG antibodies to explore its tissue-specific expression patterns, subcellular localization, and interactions with metabolic pathways. For instance, studies highlight its role in promoting mitochondrial biogenesis in muscle or modulating gluconeogenesis in the liver. Reliable ESRRG antibodies are crucial for elucidating its dual roles as a potential oncogene or tumor suppressor, depending on cellular context, and for advancing biomarker discovery in diseases like diabetes or Parkinson's.
×
