| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LAMB2; lamc1; Laminin B2 chain; Laminin subunit gamma-1; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit gamma;;Laminin gamma 1 |
| WB Predicted band size | Calculated MW: 178 kDa ; Observed MW: 200-280 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Laminin gamma 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Laminin gamma1(LAMC1)抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*Laminin γ1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve*
**作者**：Yu WM, et al.
**摘要**：该研究利用Laminin gamma1特异性抗体，通过免疫组化和基因敲除技术，揭示了Laminin γ1在周围神经系统中促进雪旺细胞分化和轴突髓鞘形成的关键作用，并发现其抗体可应用于神经损伤修复的功能研究。
2. **文献名称**：*Targeting Laminin γ1 suppresses angiogenesis in malignant mesothelioma*
**作者**：Nishiuchi R, et al.
**摘要**：研究通过抗Laminin γ1抗体的阻断实验，证明其可抑制恶性间皮瘤血管生成，并利用Western blot和免疫荧光技术验证了Laminin γ1在肿瘤微环境中的高表达及其作为治疗靶点的潜力。
3. **文献名称**：*LAMC1 promotes tumor progression and metastasis in oral squamous cell carcinoma*
**作者**：Chen J, et al.
**摘要**：该文献使用Laminin γ1抗体进行免疫组织化学分析，发现LAMC1在口腔鳞癌中高表达，且与淋巴结转移和不良预后相关，提示其抗体在癌症诊断和预后评估中的应用价值。
The Laminin gamma1 (LAMC1) antibody targets the gamma-1 chain of laminin, a critical component of the extracellular matrix (ECM). Laminins are heterotrimeric glycoproteins composed of alpha, beta, and gamma chains, with LAMC1 being essential for forming basement membranes (BMs) that support tissue structure and cell adhesion. The gamma-1 chain is ubiquitously expressed and participates in diverse biological processes, including cell differentiation, migration, and tissue development.
Research on LAMC1 antibodies has focused on its role in diseases such as cancer, fibrosis, and genetic disorders. In cancer, elevated LAMC1 expression correlates with tumor progression, metastasis, and poor prognosis, likely due to its involvement in ECM remodeling and angiogenesis. Antibodies against LAMC1 are utilized to study these mechanisms, identify therapeutic targets, or serve as diagnostic markers. For example, they have been applied in immunohistochemistry (IHC) and Western blotting to assess LAMC1 levels in tumor tissues or biofluids.
Additionally, LAMC1 mutations are linked to epidermolysis bullosa and other BM-related disorders, driving interest in antibodies for diagnostic confirmation. Recent studies also explore its role in tissue regeneration and stem cell niches. Despite its significance, challenges remain in developing isoform-specific antibodies due to structural homology among laminin subunits. Overall, LAMC1 antibodies are vital tools for unraveling ECM biology and advancing translational research.
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