| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | gf2bp2; IMP2; p62; VICKZ2;;IGF2BP2 |
| WB Predicted band size | Calculated MW: 66 kDa ; Observed MW: 66,62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human IGF2BP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于IMP2抗体的3篇参考文献示例(内容为模拟虚构，仅供参考)：
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1. **文献名称**: *IMP2 Antibody as a Novel Biomarker in Colorectal Cancer Prognosis*
**作者**: Zhang L, et al.
**摘要**: 本研究开发了一种高特异性IMP2单克隆抗体，并通过免疫组化分析发现IMP2在结直肠癌组织中显著过表达。结果显示，IMP2的高表达与患者总生存期缩短相关，提示其作为预后标志物的潜力。
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2. **文献名称**: *Development and Validation of a Rabbit Polyclonal Antibody Against IMP2 for Western Blot Applications*
**作者**: Smith JR, et al.
**摘要**: 文章报道了一种兔源多克隆IMP2抗体的制备与验证。该抗体在Western blot中表现出高特异性，成功检测到多种癌细胞系中IMP2蛋白的表达水平，为后续功能研究提供了可靠工具。
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3. **文献名称**: *IMP2 Expression in Hepatocellular Carcinoma: Insights from Immunohistochemical Staining*
**作者**: Tanaka K, et al.
**摘要**: 利用商业化IMP2抗体对肝细胞癌组织进行免疫组化分析，发现IMP2在肿瘤边缘区域的表达显著升高，并与肿瘤侵袭性正相关，提示其在癌症转移中的潜在作用。
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注：以上文献为示例性质，实际研究中请通过PubMed或Google Scholar检索真实文献(关键词：IMP2 antibody, IGF2BP2. cancer biomarker)。
The IMP2 antibody targets Insulin-like Growth Factor 2 mRNA-Binding Protein 2 (IMP2/IGF2BP2), a member of the conserved RNA-binding protein family involved in post-transcriptional gene regulation. IMP2 binds to mRNA transcripts, stabilizing them and modulating translation, thereby influencing cell proliferation, differentiation, and metabolism. It is highly expressed during embryonic development but shows restricted expression in adult tissues, except in pathological conditions like cancer. IMP2 is implicated in tumors such as glioblastoma, hepatocellular carcinoma, and sarcoma, where it promotes oncogenesis by regulating cancer-associated mRNAs (e.g., c-MYC, HMGA1). It also links to metabolic disorders, including type 2 diabetes, due to its role in insulin signaling and glucose homeostasis.
The IMP2 antibody is widely used in research to study its expression patterns, molecular interactions, and pathological roles. Applications include Western blotting, immunohistochemistry, and immunofluorescence to quantify protein levels or localize IMP2 in tissues/cells. Commercially available antibodies are typically validated for specificity, often targeting unique epitopes within its RNA-binding domains or linker regions. Recent studies explore IMP2 as a therapeutic target, with antibodies investigated for diagnostic or inhibitory potential in cancers. However, challenges remain in distinguishing IMP2 from homologous family members (IMP1/IMP3) due to structural similarities, necessitating careful validation in experimental settings.
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