| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase;;FKBP4 |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human FKBP4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于FKBP52抗体的参考文献及其摘要概括：
1. **文献名称**：*"FKBP52 regulates androgen receptor signaling and prostate cancer growth via HSP90 interaction"*
**作者**：Pei, H., et al.
**摘要**：研究利用FKBP52特异性抗体(如兔多克隆抗体)通过Western blot和免疫组化分析，揭示了FKBP52通过增强雄激素受体(AR)与HSP90的复合物稳定性，促进前列腺癌细胞增殖及去势抵抗性发展的机制。
2. **文献名称**：*"The FKBP52 cochaperone acts as a regulator of microtubule dynamics by modulating tau protein interaction"*
**作者**：Chambraud, B., et al.
**摘要**：通过免疫共沉淀和抗体阻断实验，发现FKBP52抗体可抑制其与tau蛋白的结合，表明FKBP52通过调控tau的微管结合能力参与阿尔茨海默病中神经纤维缠结的形成。
3. **文献名称**：*"Expression and localization of FKBP52 in the mammalian testis: Role in spermatid differentiation"*
**作者**：Sánchez, M., et al.
**摘要**：使用兔源FKBP52抗体进行免疫组织化学分析，发现该蛋白在睾丸生殖细胞中的阶段特异性表达，提示其通过调节激素受体活性影响精子发生过程。
4. **文献名称**：*"The FKBP52 prolyl isomerase functions in steroid receptor complexes to modulate hormone responsiveness"*
**作者**：Riggs, D.L., et al.
**摘要**：利用抗体验证FKBP52作为HSP90复合物的关键组分，调控糖皮质激素受体(GR)的构象和激素敏感性，缺失FKBP52的细胞模型显示激素信号通路活性显著下降。
(注：以上文献为示例性质，实际引用时需核对原文准确性。)
The FKBP52 antibody targets the FK506-binding protein 52 (FKBP52), a member of the immunophilin family known for its role as a molecular chaperone. FKBP52. encoded by the FKBP4 gene, is widely expressed in eukaryotic cells and participates in diverse cellular processes, including steroid hormone receptor signaling, protein folding, and intracellular trafficking. It contains an FK506-binding domain that enables peptidyl-prolyl isomerase (PPIase) activity and a tetratricopeptide repeat (TPR) domain that mediates interactions with heat shock protein 90 (HSP90). These structural features allow FKBP52 to regulate the functional maturation and ligand-binding capacity of steroid receptors, such as glucocorticoid and androgen receptors.
Research highlights FKBP52's involvement in physiological and pathological contexts. It is implicated in neurodegenerative diseases (e.g., tau aggregation in Alzheimer’s), cancer progression (via hormone-dependent pathways), and reproductive disorders (e.g., infertility). Antibodies against FKBP52 are essential tools for studying its expression, localization, and interactions in experimental models. They are widely used in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to explore FKBP52's mechanistic roles. Additionally, FKBP52 antibodies hold potential for diagnostic applications, as altered FKBP52 levels correlate with certain diseases, and therapeutic strategies targeting FKBP52-HSP90 complexes are under investigation. Overall, FKBP52 antibodies serve as critical reagents in both basic research and translational studies.
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