| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AIG6; FKBP5; FKBP51; FKBP54; P54; PPIase; PPIase FKBP5; Ptg10;Rotamase;;FKBP5 |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthesized peptide derived from human FKBP5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于FKBP51抗体的示例性参考文献(基于真实研究背景构建的示例，非真实文献)：
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1. **文献名称**：*FKBP51 regulates glucocorticoid receptor signaling in stress-related disorders*
**作者**：Binder, E.B. et al.
**摘要**：该研究通过Western blot和免疫组化技术，利用FKBP51特异性抗体揭示了FKBP51在调节糖皮质激素受体信号通路中的作用，发现其在应激相关精神疾病(如抑郁症)中的表达异常可能影响HPA轴功能。
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2. **文献名称**：*FKBP51 modulates metabolic pathways in obesity and diabetes*
**作者**：Hartmann, J. et al.
**摘要**：研究通过免疫沉淀和免疫荧光技术，使用FKBP51抗体证明其在脂肪细胞中与胰岛素信号通路相互作用，提示FKBP51可能作为代谢疾病的潜在治疗靶点。
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3. **文献名称**：*FKBP51 antibody-based detection in Alzheimer's disease models*
**作者**：Medina, D. et al.
**摘要**：该文献报道了一种高特异性FKBP51抗体的开发，并应用于阿尔茨海默病小鼠模型的脑组织分析，发现FKBP51与tau蛋白异常磷酸化相关，可能参与神经退行性病变机制。
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4. **文献名称**：*FKBP51 interacts with Akt in cancer cell survival*
**作者**：Sanchez, G. et al.
**摘要**：通过免疫共沉淀和流式细胞术，研究发现FKBP51在乳腺癌细胞中通过结合Akt蛋白促进细胞存活，相关抗体实验为靶向FKBP51的癌症治疗提供了依据。
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注：以上内容为示例性质，具体文献需通过PubMed或Web of Science检索关键词“FKBP51 antibody”获取。
FKBP51 (FK506-binding protein 51) is a member of the immunophilin protein family, primarily recognized for its role in regulating steroid hormone receptor signaling, stress responses, and protein folding. It functions as a cochaperone in the Hsp90 (heat shock protein 90) complex, influencing the activity of glucocorticoid receptors (GR) and other nuclear receptors. Dysregulation of FKBP51 has been implicated in stress-related disorders (e.g., depression, anxiety), metabolic syndromes, neurodegenerative diseases (e.g., Alzheimer’s), and chronic pain. Its overexpression is linked to glucocorticoid resistance and pathological tau aggregation.
FKBP51 antibodies are essential tools for studying its expression, localization, and interactions in cells and tissues. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research into FKBP51’s mechanistic roles in disease. Specific antibodies target distinct epitopes, allowing differentiation between FKBP51 and its homolog FKBP52. which shares structural similarities but opposes GR regulation. Recent studies also explore FKBP51 as a therapeutic target, with antibodies potentially aiding drug development. Validated FKBP51 antibodies are critical for understanding its dual roles in stress adaptation and disease progression, offering insights for biomarker discovery and targeted therapies.
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