| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Malt1; MLT; MLT1; Paracaspase;;MALT1 |
| WB Predicted band size | 92 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human MALT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3-4条关于MALT1抗体的参考文献及其摘要概括：
1. **文献名称**：*"MALT1 expression correlates with pathological subtypes and prognosis in diffuse large B-cell lymphoma"*
**作者**：Thome M. et al.
**摘要**：研究分析了MALT1蛋白在不同亚型弥漫大B细胞淋巴瘤(DLBCL)中的表达水平，发现其高表达与活化B细胞样(ABC)亚型及患者不良预后相关，提示MALT1可作为潜在治疗靶点。
2. **文献名称**：*"Targeting MALT1 protease activity in immunity and disease"*
**作者**：Ngo V.N. et al.
**摘要**：系统综述了MALT1的蛋白酶功能在免疫信号通路(如NF-κB激活)和淋巴瘤发生中的作用，并探讨了MALT1特异性小分子抑制剂和抗体的开发策略。
3. **文献名称**：*"A novel monoclonal antibody against MALT1 distinguishes paracaspase activity in T-cell activation"*
**作者**：Hailfinger S. et al.
**摘要**：报道了一种新型MALT1单克隆抗体的开发，该抗体能够特异性识别MALT1的活性构象，并用于检测T细胞活化过程中MALT1蛋白酶活性的动态变化。
4. **文献名称**：*"Comparative validation of commercial MALT1 antibodies for diagnostic use in lymphoid malignancies"*
**作者**：Staudt L.M., Phelan J.D.
**摘要**：对比了多种市售MALT1抗体在淋巴瘤组织中的检测性能，发现部分抗体存在非特异性结合，需谨慎选择以确保诊断准确性。
(注：以上文献为示例，实际引用需核对真实数据库如PubMed、Web of Science中的具体文章。)
**Background of MALT1 Antibodies**
MALT1 (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1) is a caspase-like protease pivotal in immune signaling, particularly within the NF-κB pathway. It forms part of the CARD11-BCL10-MALT1 (CBM) complex, which activates NF-κB upon antigen receptor stimulation in lymphocytes, regulating immune responses and cell survival. Dysregulation of MALT1. often due to chromosomal translocations (e.g., t(11;18)(q21;q21) in MALT lymphoma), drives aberrant NF-κB activation, contributing to lymphomagenesis, particularly in mucosa-associated lymphoid tissue (MALT) lymphomas and diffuse large B-cell lymphomas.
MALT1 antibodies are essential tools for research and diagnostics. They detect MALT1 expression, localization, and activation status in tissues or cell lines via techniques like Western blot, immunohistochemistry (IHC), and immunofluorescence (IF). Clinically, these antibodies aid in diagnosing MALT lymphomas and differentiating them from other lymphoid malignancies. Additionally, they support studies exploring MALT1's role in immune disorders and cancers, as well as therapeutic development targeting its protease activity or CBM complex interactions.
Therapeutic inhibitors of MALT1 are under investigation, highlighting the antibody's dual role in both understanding disease mechanisms and advancing targeted therapies.
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