| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ECP54; Pontin 52; PONTIN; RuvB like 1; RUVBL1; RVB1; TAP54 alpha; TIP49; TIP49a;;RUVBL1 |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human RUVBL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于TIP49A抗体的3-4条参考文献示例(内容基于公开研究整理，文献标题和作者为虚构示例，供参考)：
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1. **文献名称**: *TIP49a in oncogenesis: A novel therapeutic target*
**作者**: Izumikawa, K., et al.
**摘要**: 该研究探讨了TIP49A(RUVBL1)在多种癌症中的过表达现象，利用特异性抗体通过免疫组化分析发现其与肿瘤增殖和转移相关，提示其作为癌症生物标志物和治疗靶点的潜力。
2. **文献名称**: *Structural insights into TIP49A-antibody interactions by cryo-EM*
**作者**: López-Perrote, A., et al.
**摘要**: 通过冷冻电镜技术解析了TIP49A蛋白与其单克隆抗体的复合物结构，揭示了抗体结合表位的关键区域，为开发靶向TIP49A的抑制剂提供结构基础。
3. **文献名称**: *Development of a high-affinity monoclonal antibody against TIP49A for chromatin remodeling studies*
**作者**: Yokoyama, N., et al.
**摘要**: 研究报道了一种高特异性抗体的开发，该抗体成功用于染色质免疫沉淀(ChIP)实验，证实TIP49A在DNA损伤修复中与BRG1复合体的协同作用。
4. **文献名称**: *TIP49A antibody-based detection in neurodegenerative disease models*
**作者**: Chen, L., et al.
**摘要**: 利用TIP49A抗体在小鼠脑组织样本中发现其异常聚集现象，提示其可能参与神经退行性疾病中蛋白质稳态失调的病理过程。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“TIP49A antibody”“RUVBL1 antibody”获取最新研究。
TIP49A antibody targets the TIP49A protein, also known as RUVBL1 (RuvB-like AAA ATPase 1), a conserved member of the AAA+ (ATPases Associated with Diverse Cellular Activities) superfamily. TIP49A plays critical roles in chromatin remodeling, transcriptional regulation, and DNA repair by facilitating ATP-dependent processes. It interacts with various multiprotein complexes, including the INO80 and SWR1 chromatin remodelers, and the TIP60 histone acetyltransferase complex, influencing nucleosome positioning, histone variant exchange, and gene expression. TIP49A also participates in cell cycle regulation, telomere maintenance, and oncogenic signaling pathways, with dysregulation linked to cancers, such as colorectal and breast malignancies.
The TIP49A antibody is a vital tool for studying these processes. It is commonly used in Western blotting, immunoprecipitation, and immunofluorescence to detect protein expression, localization, and interactions in cellular or tissue samples. Researchers employ it to investigate TIP49A’s functional partnerships (e.g., with TIP49B/RUVBL2) and its role in diseases. Validated antibodies ensure specificity for TIP49A, distinguishing it from related AAA+ proteins. Its applications extend to cancer research, where TIP49A’s overexpression or mutation is explored as a potential therapeutic target. Overall, this antibody supports mechanistic insights into chromatin dynamics, genome stability, and disease pathogenesis.
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