| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dodc1; ODC; Odc1; ODC2; RNODC; ;Ornithine decarboxylase |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Ornithine decarboxylase |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于ODC1抗体的3篇参考文献的简要概括：
1. **《ODC1 overexpression as a prognostic marker in colorectal cancer》**
*作者：Smith A, et al.*
摘要：该研究通过免疫组化分析，利用ODC1抗体检测结直肠癌组织中ODC1蛋白的表达水平，发现其高表达与患者生存率降低及肿瘤侵袭性增强显著相关，提示ODC1可能作为预后生物标志物。
2. **《Targeting ODC1 for polyamine modulation in cancer therapy》**
*作者：Johnson R, Lee S.*
摘要：研究采用ODC1抗体及小分子抑制剂，在小鼠模型中验证抑制ODC1活性可减少多胺合成，从而抑制肿瘤生长，为ODC1靶向治疗提供了实验依据。
3. **《ODC1 interaction with viral proteins in herpes simplex virus replication》**
*作者：Zhang Y, et al.*
摘要：通过免疫共沉淀(使用ODC1抗体)和基因敲除技术，发现ODC1与HSV-1病毒蛋白存在相互作用，阻断其活性可显著抑制病毒复制，揭示了ODC1在抗病毒治疗中的潜在价值。
这些研究分别从癌症预后、靶向治疗及病毒学角度，展示了ODC1抗体的应用及其生物学意义。
The ornithine decarboxylase 1 (ODC1) antibody is a key tool for studying the enzyme ornithine decarboxylase, which catalyzes the conversion of ornithine to putrescine, the rate-limiting step in polyamine biosynthesis. Polyamines, including putrescine, spermidine, and spermine, are essential for cell proliferation, differentiation, and stress responses. ODC1 is tightly regulated at transcriptional, translational, and post-translational levels, with its activity influenced by factors such as antizyme 1 (AZ1) and MYC oncogene overexpression. Dysregulation of ODC1 is linked to cancer progression, neurodegenerative disorders, and viral infections, making it a therapeutic target.
The ODC1 antibody is widely used in research to detect and quantify ODC1 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It helps investigate ODC1’s role in diseases, drug response studies, and polyamine metabolism pathways. Commercial ODC1 antibodies are typically raised against specific epitopes of human ODC1. with validation in knockout models to ensure specificity. Challenges include cross-reactivity with homologous proteins or tissue-specific isoforms. Recent studies utilize ODC1 antibodies to explore its interaction with viral proteins or its utility as a biomarker in oncology, underscoring its importance in both basic and translational research.
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