| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BCK; Ckb; CKBB; HEL 211; HEL S 29;;Creatine kinase B type |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Creatine kinase B type |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下为3篇与Creatine Kinase B型(CK-BB)抗体相关的文献信息，格式为简化版：
1. **文献名称**: "Creatine kinase BB as a cancer biomarker"
**作者**: Smith J et al.
**摘要**: 研究验证了CK-BB抗体在多种癌症组织中的特异性表达，发现其与神经内分泌肿瘤和转移性前列腺癌相关，提示其作为癌症生物标志物的潜力。
2. **文献名称**: "Immunohistochemical localization of brain-type creatine kinase in cardiac tissue"
**作者**: Lee S et al.
**摘要**: 利用CK-BB特异性抗体检测心肌缺血损伤模型，发现CK-BB在缺血后心肌细胞线粒体中的异常表达，为心脏疾病病理机制提供新视角。
3. **文献名称**: "Development of a high-sensitivity ELISA for human creatine kinase B subunit"
**作者**: Tanaka M et al.
**摘要**: 开发了一种基于单克隆CK-BB抗体的新型ELISA检测法，灵敏度达0.1 ng/mL，成功应用于脑损伤患者脑脊液中CK-BB的微量检测。
注：以上文献名为示例性质，实际研究中建议通过PubMed等数据库以关键词 "Creatine Kinase B-type antibody" / "CK-BB antibody" 结合具体应用领域(如cancer, neurological disorders)检索近年高质量论文。
Creatine kinase B-type (CK-BB) is an enzyme belonging to the creatine kinase family, which plays a critical role in cellular energy metabolism by catalyzing the reversible transfer of phosphate groups between creatine and adenosine triphosphate (ATP). The CK-BB isoform is predominantly expressed in brain tissue, smooth muscle, and certain tumors, distinguishing it from other isoforms like CK-MB (cardiac/skeletal muscle) and CK-MM (skeletal muscle). Antibodies targeting CK-BB are essential tools in biomedical research and diagnostics, particularly for studying neurological disorders, brain injury, and cancers where CK-BB overexpression is observed, such as small cell lung carcinoma or prostate cancer.
These antibodies are typically monoclonal or polyclonal, designed to recognize specific epitopes on the B-subunit of the enzyme. They enable detection and quantification of CK-BB through techniques like ELISA, Western blotting, or immunohistochemistry. In clinical settings, CK-BB antibodies aid in differentiating tissue-specific damage; for example, elevated CK-BB in cerebrospinal fluid may indicate acute brain injury or stroke. However, cross-reactivity with other isoforms remains a challenge, necessitating rigorous validation. Advances in antibody engineering, such as high-affinity recombinant antibodies, continue to enhance specificity and diagnostic accuracy, reinforcing CK-BB's role as a biomarker in both research and precision medicine.
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