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Rabbit Monoclonal TMPRSS2 Antibody

  • 中文名： TMPRSS2抗体
  • 别    名： Epitheliasin; PRSS10; TMPRSS2;;TMPRSS2
货号: IPDX18328
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesEpitheliasin; PRSS10; TMPRSS2;;TMPRSS2
WB Predicted band size54 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human TMPRSS2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于TMPRSS2抗体的参考文献概述(模拟虚构内容，仅供格式参考)：

1. **文献名称**：*TMPRSS2 and COVID-19: Serine protease activation in SARS-CoV-2 invasion*

**作者**：Hoffmann M, et al.

**摘要**：研究证实TMPRSS2通过切割SARS-CoV-2刺突蛋白介导病毒进入宿主细胞，并验证了其抗体在阻断病毒感染中的潜在应用。

2. **文献名称**：*Prostate cancer biomarkers: TMPRSS2-ERG fusion protein detection using monoclonal antibodies*

**作者**：Tomlins SA, et al.

**摘要**：开发了一种特异性识别TMPRSS2-ERG融合蛋白的单克隆抗体，用于前列腺癌病理诊断和预后评估。

3. **文献名称**：*Comparative analysis of commercial TMPRSS2 antibodies for immunohistochemistry*

**作者**：Bertram S, et al.

**摘要**：系统评估了多种市售TMPRSS2抗体的灵敏度和特异性，为呼吸道及前列腺组织研究提供抗体选择依据。

(注：以上文献为示例，实际引用请查询PubMed等数据库获取真实文献。)

背景信息

TMPRSS2 (transmembrane protease, serine 2) is a cell surface-associated serine protease that plays a critical role in cleaving and activating viral envelope proteins, including the spike protein of SARS-CoV-2. facilitating viral entry into host cells. Antibodies targeting TMPRSS2 are primarily used as research tools to study its expression, localization, and function in physiological and pathological contexts. These antibodies enable the detection of TMPRSS2 in various tissues, such as the respiratory and urogenital tracts, where it is highly expressed. In COVID-19 research, TMPRSS2 inhibitors and neutralizing antibodies have been explored to block viral infection by preventing spike protein cleavage. Beyond virology, TMPRSS2 antibodies are applied in cancer studies, particularly prostate cancer, where TMPRSS2-ERG gene fusions are common oncogenic drivers. Commercially available TMPRSS2 antibodies include monoclonal and polyclonal variants, validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Challenges remain in ensuring antibody specificity due to structural similarities among serine protease family members. Recent studies also investigate TMPRSS2's role in hormonal signaling and its potential as a therapeutic target for viral and neoplastic diseases. These antibodies continue to support fundamental research into protease-mediated cellular mechanisms and disease pathways.

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