| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NIPK; SINK; SKIP3; TRB3; Trib3; Tribbles3;;TRIB3 |
| WB Predicted band size | 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human TRIB3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于TRIB3抗体的3篇参考文献示例(注：内容为模拟概括，实际文献需查询数据库确认)：
---
1. **文献名称**: *TRIB3 regulates autophagy and apoptosis in cancer cells through mTOR signaling*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用TRIB3特异性抗体，通过免疫印迹和免疫荧光技术，揭示了TRIB3通过抑制mTOR通路调控肿瘤细胞自噬和凋亡的分子机制，为癌症治疗提供了潜在靶点。
---
2. **文献名称**: *TRIB3 as a biomarker for insulin resistance in type 2 diabetes*
**作者**: Li H, Wang X.
**摘要**: 研究通过ELISA和免疫组化分析糖尿病患者组织样本，发现TRIB3抗体检测的高表达水平与胰岛素抵抗显著相关，提示其作为代谢疾病生物标志物的价值。
---
3. **文献名称**: *Antibody-based targeting of TRIB3 enhances chemosensitivity in colorectal cancer*
**作者**: Chen L, et al.
**摘要**: 该研究开发了一种高亲和力TRIB3单克隆抗体，并证明其可通过阻断TRIB3与AKT相互作用，提高结直肠癌细胞对化疗药物的敏感性，为联合治疗提供新策略。
---
如需具体文献，建议通过PubMed或Google Scholar以关键词“TRIB3 antibody”或“TRIB3 biomarker”检索最新研究。
TRIB3 (Tribbles homolog 3) antibodies are essential tools for studying the role of TRIB3. a pseudokinase protein belonging to the Tribbles family. TRIB3 acts as a stress-inducible regulator involved in diverse cellular processes, including proliferation, apoptosis, metabolic stress response, and autophagy. Unlike typical kinases, TRIB3 lacks enzymatic activity but modulates signaling pathways by interacting with key molecules such as AKT, MAPK, and transcription factors like ATF4. It is notably implicated in endoplasmic reticulum (ER) stress responses through the unfolded protein response (UPR) pathway. Dysregulation of TRIB3 is linked to cancer progression, metabolic disorders (e.g., diabetes, obesity), and neurodegenerative diseases, making it a focus for therapeutic research.
TRIB3 antibodies enable the detection and quantification of TRIB3 expression in tissues or cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use these antibodies to explore TRIB3’s dual roles—for instance, its pro-survival function in cancer cells by inhibiting apoptosis or its contribution to insulin resistance in metabolic diseases. Additionally, TRIB3 antibodies help evaluate its potential as a biomarker for disease prognosis or treatment response. Commercial TRIB3 antibodies are typically validated for specificity against human, mouse, or rat isoforms, supporting translational studies across models. Understanding TRIB3’s context-dependent mechanisms remains critical for developing targeted therapies.
×
