| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | p70 beta; P70S6K2; p70S6Kb; Rps6kb2; S6K beta 2; S6K beta; S6K2; SRK; STK14B;;p70 S6 kinase beta 2 |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human p70 S6 kinase beta 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于p70S6Kβ抗体的虚构参考文献示例(仅供说明用途)：
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1. **文献名称**: *Differential Roles of p70S6K Isoforms in mTORC1 Signaling*
**作者**: Tanaka M, et al.
**摘要**: 本研究通过特异性p70S6Kβ抗体，揭示了该亚型在mTORC1通路中对核糖体生物合成的独特调控作用，区别于α亚型的细胞生长功能。
2. **文献名称**: *p70S6Kβ Overexpression in Glioblastoma Drives Therapeutic Resistance*
**作者**: Chen R, et al.
**摘要**: 利用p70S6Kβ抗体进行免疫组化分析，发现其在胶质母细胞瘤中高表达，并通过激活下游蛋白合成通路促进化疗耐药性。
3. **文献名称**: *Phosphorylation Dynamics of p70S6Kβ in Insulin Signaling*
**作者**: Gupta S, et al.
**摘要**: 通过Western blot结合p70S6Kβ抗体，阐明胰岛素刺激下该激酶Thr389位点的磷酸化动态，及其与代谢综合征的潜在关联。
4. **文献名称**: *Development of a Novel p70S6Kβ-Specific Antibody for Functional Studies*
**作者**: Park J, et al.
**摘要**: 报道了一种高特异性p70S6Kβ抗体的开发与验证，证明其在区分同源异构体及肿瘤模型中的精准检测能力。
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(注：以上文献为模拟示例，实际引用需检索PubMed等数据库获取真实文献。)
The p70 S6 Kinase beta (p70S6Kβ), also known as S6K2. is a serine/threonine kinase belonging to the AGC family, which plays a critical role in the PI3K/AKT/mTOR signaling pathway. This pathway regulates cell growth, proliferation, and survival in response to nutrients, growth factors, and cellular stress. p70S6Kβ shares structural homology with its isoform p70S6Kα (S6K1) but exhibits distinct tissue-specific expression patterns and subcellular localization. It is activated via phosphorylation by mTORC1 and PDK1. facilitating downstream processes such as ribosome biogenesis, protein synthesis, and cell cycle progression by phosphorylating targets like the ribosomal protein S6.
Antibodies targeting p70S6Kβ are essential tools for studying its expression, activation, and functional roles in physiological and pathological contexts, including cancer, metabolic disorders, and aging. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect total protein levels or phosphorylation status at specific residues (e.g., Thr389). High-quality p70S6Kβ antibodies are validated for specificity to avoid cross-reactivity with p70S6Kα, ensuring accurate interpretation of isoform-specific signaling.
Research utilizing p70S6Kβ antibodies has highlighted its unique contributions to mTOR-dependent processes, such as regulating mRNA translation and cellular stress responses, providing insights into therapeutic targeting of mTOR-related diseases.
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