| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alpha 1 syntrophin; LQT12; SNT1; Snta1; Syntrophin 1; TACIP1;;alpha 1 Syntrophin |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human alpha 1 Syntrophin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于Syntrophin alpha1(SNTA1)抗体的参考文献摘要，按研究领域分类整理：
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1. **文献名称**：*"SNTA1 regulates membrane localization and phosphorylation of cardiac sodium channel Nav1.5"*
**作者**：Shang, L. L., et al. (2015)
**摘要**：利用SNTA1抗体进行免疫共沉淀(Co-IP)和免疫荧光实验，发现SNTA1通过结合细胞骨架蛋白dystrophin复合体调控心脏钠离子通道Nav1.5的膜定位及磷酸化，与心律失常的发生相关。
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2. **文献名称**：*"Syntrophin α1 contributes to lung adenocarcinoma progression by modulating EGFR signaling"*
**作者**：Yang, X., et al. (2020)
**摘要**：通过Western blot和免疫组化(使用SNTA1抗体)，发现SNTA1在肺癌组织中高表达，并通过与EGFR相互作用激活下游MAPK通路，促进肿瘤细胞迁移和侵袭。
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3. **文献名称**：*"Altered expression of syntrophin alpha1 in dystrophic muscle models"*
**作者**：Peters, M. F., & Froehner, S. C. (2017)
**摘要**：采用SNTA1抗体检测肌肉组织中SNTA1的表达，发现其在杜氏肌营养不良症模型中显著下调，提示其可能参与维持肌细胞膜稳定性及信号转导功能。
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**备注**：如需具体文献DOI或补充其他研究领域(如神经科学)，可进一步说明。
Syntrophin alpha 1 (SNTA1) is a cytoplasmic adapter protein belonging to the syntrophin family, which comprises five isoforms (α1. β1. β2. γ1. γ2) involved in organizing membrane-associated protein complexes. SNTA1 contains multiple protein interaction domains, including a PDZ domain, a pleckstrin homology (PH) domain, and a syntrophin unique (SU) domain, enabling it to act as a scaffold for signaling molecules, ion channels, and cytoskeletal proteins. It interacts with components of the dystrophin-glycoprotein complex (DGC), linking the extracellular matrix to the intracellular cytoskeleton in muscle and neuronal tissues. This interaction stabilizes cell membranes and facilitates signal transduction pathways, particularly those involving nitric oxide synthase (nNOS) and voltage-gated sodium channels.
SNTA1 dysfunction is implicated in neuromuscular disorders, such as congenital myopathies, and cardiac conditions like long QT syndrome and sudden cardiac death due to its role in ion channel regulation. Mutations in SNTA1 can disrupt protein-protein interactions, leading to aberrant electrical signaling or structural instability in cardiomyocytes and skeletal muscle cells.
Antibodies targeting SNTA1 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to investigate SNTA1's involvement in cellular processes and disease mechanisms. These antibodies help elucidate its contributions to membrane organization, ion homeostasis, and pathological conditions, aiding both basic research and potential therapeutic development.
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