| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2 |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human LGALS3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PWP1抗体的模拟参考文献示例(仅供示例参考，非真实文献)：
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1. **文献名称**：*PWP1 regulates ribosome biogenesis and cell cycle progression through 18S rRNA processing*
**作者**：Smith J, et al.
**摘要**：本研究利用PWP1特异性抗体，通过免疫荧光和Western blot技术，揭示了PWP1蛋白在核仁中的定位及其在18S rRNA加工中的关键作用。实验表明，PWP1缺失导致细胞周期停滞在G1期，提示其通过调控核糖体合成影响细胞增殖。
2. **文献名称**：*Characterization of PWP1 antibody for detecting dysregulation in cancer models*
**作者**：Chen L, et al.
**摘要**：作者开发了一种高特异性PWP1单克隆抗体，并验证了其在结直肠癌组织中的表达显著下调。通过免疫组化分析，发现PWP1低表达与患者预后不良相关，提示其可能作为肿瘤抑制因子的潜在生物标志物。
3. **文献名称**：*Interaction network of PWP1 in the nucleolar proteome revealed by co-immunoprecipitation*
**作者**：Müller R, et al.
**摘要**：利用PWP1抗体进行免疫共沉淀联合质谱分析，鉴定了PWP1与UTP复合物成员的相互作用，证实了其在pre-rRNA加工复合体中的核心地位，并发现其与遗传性发育障碍的相关突变位点。
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**备注**：以上文献为模拟内容，实际研究中请通过PubMed、Web of Science等平台检索真实文献。若需具体论文推荐，建议结合关键词“PWP1 antibody”、“PWP1 function”或“PWP1 ribosome”进行查询。
The PWP1 antibody is a tool used to detect PWP1 (Periodic Tryptophan Protein 1), a conserved protein belonging to the WD40 repeat family. PWP1 is a component of the UTP-B (U3 small nucleolar ribonucleoprotein particle) complex, which plays a critical role in ribosomal RNA (rRNA) processing, particularly during the early stages of 18S rRNA maturation. This protein is essential for ribosome biogenesis, linking its function to cellular growth, proliferation, and homeostasis. Dysregulation of PWP1 has been implicated in developmental disorders and diseases like cancer, where altered ribosome synthesis may drive uncontrolled cell division.
The PWP1 antibody is commonly used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to study PWP1 expression, localization, and interactions. It helps researchers explore PWP1's role in nucleolar organization, its association with rRNA transcription/processing machinery, and potential contributions to pathological conditions. Species reactivity typically includes humans, mice, and rats, with validation in specific cell lines or tissues. Studies using this antibody have provided insights into PWP1's involvement in cell cycle regulation and its potential as a biomarker or therapeutic target in diseases linked to ribosomal dysfunction.
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