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Rabbit Monoclonal Homer1 Antibody

  • 中文名： Homer1抗体
  • 别    名： Homer; HOMER 1A; HOMER 1B; HOMER 1C; homer homolog 1; Homer1; HOMER1A; HOMER1B; HOMER1C; SYN47;;Homer 1
货号: IPDX17922
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHomer; HOMER 1A; HOMER 1B; HOMER 1C; homer homolog 1; Homer1; HOMER1A; HOMER1B; HOMER1C; SYN47;;Homer 1
WB Predicted band sizeCalculated MW: 40 kDa ; Observed MW: 45 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Homer 1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于Homer1抗体的3篇参考文献示例(注：文献信息为模拟内容，实际引用需核实)：

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1. **文献名称**: *Homer1 regulates the interaction between group I metabotropic glutamate receptors and TRPC channels*

**作者**: Yuan JP, et al.

**摘要**: 本研究通过免疫共沉淀和Western blot技术，使用Homer1特异性抗体验证了Homer1蛋白在mGluR1/5与TRPC通道复合体形成中的作用，揭示了其在钙信号调控中的关键功能。

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2. **文献名称**: *Cocaine-induced neuroadaptations in Homer1 knockout mice: Implications for addiction*

**作者**: Szumlinski KK, et al.

**摘要**: 通过免疫组化和Western blot分析，结合Homer1抗体，研究发现Homer1基因敲除小鼠在可卡因暴露后前额叶皮层Homer1b/c表达显著降低，提示其与成瘾行为中的突触可塑性相关。

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3. **文献名称**: *Altered expression of Homer1 in schizophrenia: A postmortem study*

**作者**: Kato T, et al.

**摘要**: 利用Homer1多克隆抗体对人脑组织进行免疫染色，发现精神分裂症患者海马区Homer1a蛋白水平异常升高，表明其可能与突触功能失调及疾病病理机制相关。

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**提示**：实际文献检索建议通过PubMed或Google Scholar搜索关键词“Homer1 antibody”、“Homer1 Western blot”等，并筛选涉及实验方法学或疾病机制的研究。

背景信息

The Homer1 antibody is a crucial tool in neuroscience and cell biology research, targeting Homer1 proteins—a family of scaffolding proteins involved in synaptic organization and signal transduction. Discovered in the late 1990s, Homer1 exists as two major isoforms: the short, activity-inducible Homer1a and the constitutively expressed long isoforms (Homer1b/c). These proteins contain an N-terminal Enabled/VASP homology 1 (EVH1) domain that binds proline-rich motifs in target proteins like metabotropic glutamate receptors (mGluRs), inositol trisphosphate receptors (IP3Rs), and Shank, facilitating their clustering at postsynaptic densities. Homer1 antibodies are widely used to study synaptic plasticity, calcium signaling, and receptor trafficking in neurological disorders. They help detect Homer1 expression levels, subcellular localization, and interactions in brain tissues or cultured neurons via techniques like Western blot, immunohistochemistry, and co-immunoprecipitation. Research has linked Homer1 dysregulation to neuropsychiatric conditions such as schizophrenia, addiction, and Alzheimer’s disease, as well as epilepsy and synaptic remodeling after injury. Commercial Homer1 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knockout models to ensure specificity. Their application continues to advance understanding of synaptic architecture and pathology-driven network alterations.

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