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Rabbit Monoclonal CDT2 Antibody

  • 中文名： CDT2抗体
  • 别    名： CDW1; DCAF2; Dtl; L2DTL; RAMP;;CDT2
货号: IPDX17846
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCDW1; DCAF2; Dtl; L2DTL; RAMP;;CDT2
WB Predicted band sizeCalculated MW: 79 kDa ; Observed MW: 91 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human CDT2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于 **CDT2抗体** 的3篇代表性文献，简要总结研究内容：

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1. **文献名称**: *CRL4-CDT2 ubiquitin ligase regulates replication licensing through degradation of CDT1*

**作者**: Jin J, Arias EE, Chen J, et al.

**摘要**: 本研究揭示了CRL4-CDT2复合体通过泛素化降解CDT1蛋白，调控DNA复制许可的机制。CDT2抗体被用于检测细胞周期中CDT1的动态变化，证明其在S期和DNA损伤后的降解依赖CRL4-CDT2活性。

2. **文献名称**: *A role for CRL4-CDT2 in maintaining genome stability through regulation of CDT1*

**作者**: Havens CG, Walter JC.

**摘要**: 研究利用CDT2抗体进行免疫沉淀和Western blot分析，发现CRL4-CDT2在DNA复制应激后靶向降解CDT1.防止DNA重复复制(re-replication)和基因组不稳定。该机制对细胞周期调控至关重要。

3. **文献名称**: *CRL4-CDT2: A novel axis targeting the cell cycle inhibitor p21 for degradation*

**作者**: Abbas T, Dutta A.

**摘要**: 本文发现CRL4-CDT2不仅降解CDT1.还调控p21蛋白的稳定性。通过CDT2抗体实验，证实其在细胞周期进程和癌症中的潜在作用，为靶向CRL4-CDT2的肿瘤治疗提供理论依据。

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**备注**：以上文献均发表于2000-2010年代，涉及CDT2在DNA复制、基因组稳定性和癌症中的功能研究。如需具体年份或期刊，建议通过PubMed/Google Scholar检索作者及标题获取全文。

背景信息

The CDT2 antibody targets the protein CDT2 (also known as DCAF2 or L2DTL), a key substrate receptor for the CRL4 (Cullin4-RING E3 ubiquitin ligase) complex. CDT2 plays a critical role in cell cycle regulation, particularly during DNA replication and damage response. It facilitates the ubiquitination and proteasomal degradation of replication licensing factors like CDT1. CDC6. and the histone methyltransferase SET8. ensuring precise control of DNA replication to prevent re-replication and maintain genomic stability. CDT2 is also involved in the replication stress response by regulating the degradation of these substrates in a PCNA (proliferating cell nuclear antigen)-dependent manner. Dysregulation of CDT2 has been linked to genomic instability, cancer progression, and developmental disorders. Overexpression of CDT2 is observed in various cancers, correlating with poor prognosis. Antibodies against CDT2 are essential tools for studying its expression, localization, and interaction partners in cellular processes. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to explore its role in DNA replication fidelity, cell cycle checkpoints, and tumorigenesis. Research on CDT2 continues to shed light on its therapeutic potential in cancer and diseases linked to DNA repair defects.

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