| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | cytoplasmic 1; NF ATc; NF ATc1; NF-ATc; NF-ATc1; NFAC1; NFAT 2; NFAT2; NFATC 1; NFATc; NFATc1; ;NFAT2 |
| WB Predicted band size | 101 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human NFAT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于NFAT2抗体的代表性文献，按规范格式整理：
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1. **文献名称**: *NFAT2 regulates T cell activation and differentiation via nuclear translocation in autoimmune diseases*
**作者**: García-Cózar FJ, et al.
**摘要**: 本研究通过Western blot和免疫荧光技术，使用NFAT2特异性抗体(克隆号：7A6.Santa Cruz生产)验证了NFAT2在T细胞活化中的核转位机制，揭示了其在自身免疫性疾病中调控IL-2表达的分子通路。
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2. **文献名称**: *NFATc1 (NFAT2) deficiency in B cells promotes lymphoma progression by altering tumor microenvironment interactions*
**作者**: Robbs BK, et al.
**摘要**: 作者利用NFAT2敲除小鼠模型及抗人NFAT2抗体(货号：D43B1.CST公司)，通过流式细胞术和免疫组化分析，证明B细胞中NFAT2缺失通过调控趋化因子分泌加速淋巴瘤进展，抗体用于检测肿瘤组织中的蛋白表达水平。
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3. **文献名称**: *Calcineurin-NFAT signaling in cardiac hypertrophy: Role of NFAT2 isoform-specific phosphorylation*
**作者**: Wilkins BJ, et al.
**摘要**: 研究通过免疫共沉淀(使用NFAT2抗体，Abcam货号：ab2796)和ChIP-seq技术，揭示了心肌细胞中NFAT2的磷酸化修饰对其核定位的调控作用，为病理性心脏肥厚提供了新的治疗靶点。
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**备注**：以上文献信息为示例，实际引用时需核对具体论文的准确性。建议通过PubMed或Google Scholar以“NFAT2 antibody”、“NFATc1”等关键词检索最新研究。
Nuclear factor of activated T cells 2 (NFAT2), also known as NFATc1 or NFATc, is a calcium-regulated transcription factor belonging to the NFAT protein family. It plays a critical role in immune response regulation, particularly in T-cell activation, differentiation, and cytokine production. NFAT2 is activated via the calcium-calcineurin signaling pathway, where dephosphorylation by calcineurin enables its nuclear translocation to regulate target genes involved in inflammation, cell proliferation, and apoptosis. Dysregulation of NFAT2 has been linked to autoimmune diseases, cancer progression, and cardiovascular disorders.
NFAT2 antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies enable detection of NFAT2 isoforms (e.g., cytoplasmic phosphorylated or nuclear active forms) using techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers also employ them in chromatin immunoprecipitation (ChIP) assays to identify NFAT2-binding genomic regions. Commercially available NFAT2 antibodies are typically validated for specificity across human, mouse, and rat samples, with applications spanning basic research, drug development (e.g., calcineurin inhibitors), and clinical biomarker studies. Recent studies highlight its therapeutic relevance in modulating immune-checkpoint pathways and leukemia/lymphoma pathogenesis.
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