| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CLG3; matrix metalloproteinase 13 (collagenase 3); MMP13;;MMP13 |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human MMP13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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1. **"MMP-13 as a therapeutic target for osteoarthritis" by Smith J.D. et al.**
- 摘要：探讨了MMP13在骨关节炎中降解软骨胶原的关键作用，验证了特异性抗体抑制MMP13活性可减缓疾病进展的潜力。
2. **"Monoclonal antibody targeting MMP13 inhibits tumor growth and metastasis" by Zhang L. et al.**
- 摘要：研究开发了一种靶向MMP13的单克隆抗体，证明其通过抑制肿瘤微环境中基质重塑，显著减少小鼠模型中乳腺癌的转移。
3. **"MMP13 expression and antibody-based detection in human osteoarthritis cartilage" by Tanaka M. et al.**
- 摘要：通过免疫组化分析人类骨关节炎软骨样本，验证了MMP13抗体的特异性，揭示其与疾病严重程度的相关性。
4. **"Role of MMP13 in wound healing: Insights from antibody-blocking experiments" by Chen R. et al.**
- 摘要：利用MMP13中和抗体研究其在皮肤修复中的作用，发现抑制MMP13可减少瘢痕形成并促进再生性愈合。
(注：上述文献为模拟示例，实际引用需以真实出版物为准。)
Matrix Metalloproteinase 13 (MMP13), also known as collagenase-3. is a zinc-dependent endopeptidase belonging to the MMP family. It primarily degrades extracellular matrix (ECM) components, particularly type II collagen, and plays critical roles in tissue remodeling, wound healing, and pathological processes such as osteoarthritis, cancer metastasis, and chronic inflammation. MMP13 is upregulated in response to inflammatory cytokines (e.g., IL-1β, TNF-α) and mechanical stress, making it a key mediator in connective tissue destruction and repair.
MMP13 antibodies are immunological tools designed to detect, quantify, or inhibit MMP13 activity in research and diagnostics. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to study MMP13 expression patterns in diseases, assess its role in ECM turnover, or evaluate therapeutic interventions. In cancer, MMP13 antibodies help identify tumor invasiveness and metastatic potential, while in osteoarthritis, they track cartilage degradation.
Therapeutic MMP13 inhibitors, including monoclonal antibodies, are under investigation to mitigate tissue damage in chronic diseases. However, challenges remain in ensuring antibody specificity due to structural similarities among MMPs. Recent advancements in antibody engineering aim to enhance selectivity and reduce off-target effects. Overall, MMP13 antibodies serve as vital reagents for understanding ECM biology and developing targeted therapies for MMP13-associated disorders.
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