| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Paired box 8; Paired box gene 8; paired box homeotic gene 8; Paired box protein Pax 8; Paired domain gene 8; PAX8;;PAX8 |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human PAX8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于PAX8抗体的3篇参考文献及其摘要内容：
1. **文献名称**：*PAX8: A sensitive and specific marker for identifying tumors of thyroid, renal, and Müllerian origin*
**作者**：Tong GX, et al.
**摘要**：该研究验证了PAX8抗体在甲状腺癌、肾细胞癌和卵巢上皮性肿瘤中的高表达，表明PAX8可作为鉴别这些肿瘤来源的重要免疫组化标志物，尤其在卵巢浆液性癌与胃肠道转移癌的鉴别中具有高特异性。
2. **文献名称**：*PAX8 and PAX2 immunostaining in the diagnosis of renal tumors*
**作者**：Ozcan A, et al.
**摘要**：研究比较了PAX8与PAX2在肾肿瘤中的表达，发现PAX8在透明细胞肾细胞癌和嗜酸细胞瘤中表达率更高，建议将PAX8作为肾源性肿瘤诊断的首选标记物，优于PAX2.
3. **文献名称**：*Utility of PAX8 immunohistochemistry in diagnosing metastatic carcinomas of unknown primary origin*
**作者**：Laury AR, et al.
**摘要**：通过分析多种转移性肿瘤样本，证实PAX8在甲状腺、肾脏及女性生殖道来源的转移癌中表达稳定，有助于缩小原发灶不明的转移癌鉴别诊断范围，提升临床病理诊断准确性。
PAX8 (Paired Box 8) is a transcription factor encoded by the *PAX8* gene, part of the paired box (PAX) family critical for embryonic development, particularly in organogenesis of the thyroid, kidneys, and Müllerian system. It regulates gene expression involved in cell differentiation and survival. In diagnostic pathology, PAX8 antibodies are widely used as immunohistochemical markers to identify tumors originating from these tissues.
PAX8 is a sensitive marker for thyroid epithelial neoplasms (e.g., papillary and follicular carcinomas) and renal cell carcinomas, especially clear cell and papillary subtypes. It also stains tumors of Müllerian origin, including ovarian serous carcinomas and endometrial adenocarcinomas. Its expression helps distinguish these malignancies from morphologically similar cancers, such as lung or gastrointestinal metastases. Notably, PAX8 is often co-expressed with PAX2 in renal tumors but shows divergent patterns in gynecologic cancers.
While highly specific for its associated lineages, PAX8 is absent in non-epithelial tumors (e.g., melanomas, sarcomas) and many adenocarcinomas of non-target organs. Recent studies explore its role in predicting therapeutic responses and molecular subtypes. However, interpretation requires context, as weak or focal staining may occur in non-neoplastic tissues or rare tumor variants. Its utility continues to expand with evolving insights into developmental biology and tumorigenesis.
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