| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CASP14; Caspase-14; Caspase 14; MICE; CASP-14;;Caspase 14 |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Caspase 14 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Caspase-14抗体的3篇参考文献示例(内容为模拟概括，非真实文献)：
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1. **文献名称**：*Caspase-14 regulates epidermal barrier function via protease activity in keratinocytes*
**作者**：Denecker G. et al.
**摘要**：研究通过Caspase-14抗体免疫组化及Western blot分析，揭示了Caspase-14在表皮角质形成细胞中的特异性表达，并证明其通过调控filaggrin蛋白水解参与皮肤屏障形成。
2. **文献名称**：*Role of Caspase-14 in UVB-induced skin inflammation and differentiation*
**作者**：Lippens S. et al.
**摘要**：利用Caspase-14敲除小鼠及特异性抗体，发现Caspase-14缺失导致UVB照射后皮肤炎症加剧，提示其在光损伤保护及表皮终末分化中的关键作用。
3. **文献名称**：*Aberrant expression of Caspase-14 in epithelial cancers*
**作者**：Vandenabeele P. et al.
**摘要**：通过Caspase-14抗体检测多种上皮癌组织样本，发现其在乳腺癌和结肠癌中表达显著下调，可能作为肿瘤抑制因子影响癌细胞存活与分化。
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注：以上为模拟示例，实际文献需通过PubMed/Google Scholar等平台检索确认。
Caspase-14 antibodies are immunological tools designed to detect and study caspase-14. a unique member of the caspase protease family. Unlike other caspases involved in apoptosis or inflammation, caspase-14 is primarily expressed in epithelial tissues, particularly the skin, and plays a specialized role in epidermal differentiation and barrier formation. It is crucial for processing profilaggrin into filaggrin, a protein essential for maintaining skin hydration and integrity. Research on caspase-14 has focused on its involvement in skin disorders like atopic dermatitis, psoriasis, and photoaging, as well as its potential tumor-suppressive roles in certain cancers.
Caspase-14 antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and activation in tissue samples or cell cultures. These antibodies are available as monoclonal or polyclonal variants, often validated for specificity across human, mouse, or rat models. Their development has advanced understanding of caspase-14's regulatory mechanisms, including its cleavage-dependent activation and tissue-specific functions. Studies utilizing these antibodies have also explored environmental influences, such as UV exposure, on caspase-14 activity in skin homeostasis. As caspase-14 gains attention in dermatological and oncological research, its antibodies remain critical for investigating molecular pathways underlying epidermal pathologies and developing targeted therapies.
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