WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
ICC | 1/50-1/200 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | 15 hydroxyprostaglandin dehydrogenase [NADP+]; Carbonyl reductase [NADPH] 1; CBR1; CRN; NADPH dependent carbonyl reductase 1; Prostaglandin 9 ketoreductase; SDR21C1;;CBR1 |
WB Predicted band size | 30 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | A synthesized peptide derived from human CBR1 |
Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于CBR1抗体的3篇参考文献的简要概括(注:文献信息为模拟示例,实际文献需通过数据库检索获取):
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1. **文献名称**:*"Immunohistochemical Analysis of Carbonyl Reductase 1 in Colorectal Cancer Tissues"*
**作者**:Tanaka A, et al.
**摘要**:本研究利用特异性CBR1抗体对结直肠癌组织进行免疫组化分析,发现CBR1蛋白在肿瘤细胞中显著高表达,且与化疗药物伊立替康的耐药性相关,提示CBR1可能作为预测化疗反应的潜在标志物。
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2. **文献名称**:*"Development of a Monoclonal Antibody for Human CBR1 and Its Application in Metabolic Studies"*
**作者**:Zhang Y, et al.
**摘要**:作者开发了一种高特异性人源CBR1单克隆抗体,并通过Western blot和免疫荧光验证其适用性。研究发现,CBR1在肝脏和肾脏中的表达水平与多种外源性毒素(如尼古丁代谢物)的清除效率密切相关。
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3. **文献名称**:*"CBR1 Overexpression Promotes Doxorubicin Resistance in Breast Cancer: Insights from Antibody-Based Proteomic Profiling"*
**作者**:Gupta S, et al.
**摘要**:通过CBR1抗体进行蛋白质组学分析,揭示乳腺癌细胞中CBR1的过表达通过加速阿霉素的还原代谢导致耐药性。研究强调了靶向CBR1可能逆转化疗耐药的临床潜力。
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如需具体文献,建议在PubMed或Web of Science中检索关键词“CBR1 antibody”或“Carbonyl Reductase 1 immunohistochemistry”获取最新研究。
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