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Rabbit Monoclonal CBR1 Antibody

  • 中文名: CBR1抗体
  • 别    名: 15 hydroxyprostaglandin dehydrogenase [NADP+]; Carbonyl reductase [NADPH] 1; CBR1; CRN; NADPH dependent carbonyl reductase 1; Prostaglandin 9 ketoreductase; SDR21C1;;CBR1
货号: IPDX17153
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliases15 hydroxyprostaglandin dehydrogenase [NADP+]; Carbonyl reductase [NADPH] 1; CBR1; CRN; NADPH dependent carbonyl reductase 1; Prostaglandin 9 ketoreductase; SDR21C1;;CBR1
WB Predicted band size30 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human CBR1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于CBR1抗体的3篇参考文献的简要概括(注:文献信息为模拟示例,实际文献需通过数据库检索获取):

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1. **文献名称**:*"Immunohistochemical Analysis of Carbonyl Reductase 1 in Colorectal Cancer Tissues"*

**作者**:Tanaka A, et al.

**摘要**:本研究利用特异性CBR1抗体对结直肠癌组织进行免疫组化分析,发现CBR1蛋白在肿瘤细胞中显著高表达,且与化疗药物伊立替康的耐药性相关,提示CBR1可能作为预测化疗反应的潜在标志物。

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2. **文献名称**:*"Development of a Monoclonal Antibody for Human CBR1 and Its Application in Metabolic Studies"*

**作者**:Zhang Y, et al.

**摘要**:作者开发了一种高特异性人源CBR1单克隆抗体,并通过Western blot和免疫荧光验证其适用性。研究发现,CBR1在肝脏和肾脏中的表达水平与多种外源性毒素(如尼古丁代谢物)的清除效率密切相关。

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3. **文献名称**:*"CBR1 Overexpression Promotes Doxorubicin Resistance in Breast Cancer: Insights from Antibody-Based Proteomic Profiling"*

**作者**:Gupta S, et al.

**摘要**:通过CBR1抗体进行蛋白质组学分析,揭示乳腺癌细胞中CBR1的过表达通过加速阿霉素的还原代谢导致耐药性。研究强调了靶向CBR1可能逆转化疗耐药的临床潜力。

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如需具体文献,建议在PubMed或Web of Science中检索关键词“CBR1 antibody”或“Carbonyl Reductase 1 immunohistochemistry”获取最新研究。

背景信息

The carbonyl reductase 1 (CBR1) antibody is a tool used to detect and study the CBR1 enzyme, a member of the short-chain dehydrogenase/reductase (SDR) superfamily. CBR1 is a NADPH-dependent oxidoreductase primarily involved in the reduction of endogenous and exogenous carbonyl compounds, including steroids, prostaglandins, and xenobiotics such as chemotherapeutic drugs (e.g., doxorubicin). It plays a critical role in phase I drug metabolism, detoxification, and cellular redox balance by modulating reactive oxygen species (ROS) levels. Dysregulation of CBR1 has been linked to various pathologies, including cancer, neurodegenerative disorders, and diabetic complications. In cancer, CBR1 overexpression is associated with chemoresistance due to its role in drug inactivation, while reduced activity may exacerbate oxidative stress-related damage in metabolic diseases. The CBR1 antibody enables researchers to investigate the enzyme's expression patterns, subcellular localization (cytosolic and mitochondrial), and functional roles in tissues or cell lines. It is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore CBR1's involvement in disease mechanisms, drug metabolism pathways, and therapeutic targeting strategies. Recent studies also highlight its potential as a biomarker for prognosis and treatment response in oncology.

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