| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ACP; FASN2A; ndufab1; SDAP;;NDUFAB1 |
| WB Predicted band size | Calculated MW: 17 kDa ; Observed MW: 10 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human NDUFAB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于NDUFAB1抗体的3篇参考文献示例(注：文献信息为示例性概括，具体文献需根据实际数据库检索结果调整)：
1. **标题**：*NDUFAB1作为线粒体复合体I组装关键因子的功能研究*
**作者**：Smith J, et al.
**摘要**：通过免疫沉淀和Western blot技术，研究发现NDUFAB1抗体可特异性识别其在哺乳动物线粒体中的表达，并证实其参与复合体I的组装过程，敲低NDUFAB1导致细胞呼吸链功能受损。
2. **标题**：*NDUFAB1在结直肠癌中的表达下调及其临床意义*
**作者**：Zhang L, et al.
**摘要**：利用NDUFAB1抗体进行免疫组化分析，发现其在结直肠癌组织中表达显著降低，且低表达与患者预后不良相关，提示其可能作为潜在的肿瘤抑制因子。
3. **标题**：*NDUFAB1基因突变导致线粒体脑肌病的分子机制*
**作者**：Wang Y, et al.
**摘要**：采用NDUFAB1抗体检测患者成纤维细胞中的蛋白水平，发现特定突变导致NDUFAB1稳定性下降，进而引发复合体I缺陷及能量代谢障碍，为遗传性线粒体疾病提供新机制解释。
(建议通过PubMed或Google Scholar以“NDUFAB1 antibody”为关键词检索获取真实文献。)
The NDUFAB1 antibody is a crucial tool in mitochondrial research, targeting the NDUFAB1 protein (NADH:ubiquinone oxidoreductase subunit AB1), a core component of mitochondrial Complex I in the electron transport chain. Encoded by the *NDUFAB1* gene, this highly conserved protein serves dual roles as both an acyl carrier protein (ACP) and an iron-sulfur (Fe-S) cluster-binding subunit, essential for Complex I assembly and enzymatic activity. It facilitates fatty acid synthesis and electron transfer during NADH oxidation, linking metabolic pathways to energy production.
NDUFAB1 antibodies are widely used in studies investigating mitochondrial dysfunction, which is implicated in neurodegenerative diseases (e.g., Parkinson’s, Leigh syndrome), cancer metabolism, and rare genetic disorders. Researchers employ these antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, localization, and Complex I integrity. Reduced NDUFAB1 levels are often associated with impaired oxidative phosphorylation and increased reactive oxygen species (ROS), making it a biomarker for mitochondrial health. Commercial NDUFAB1 antibodies are typically validated for specificity across human and model organisms, aiding mechanistic studies of diseases linked to Complex I deficiencies. Its conserved structure and functional significance underscore its relevance in both basic and clinical research contexts.
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