| WB | 咨询技术 | E.coli |
| IF | 咨询技术 | E.coli |
| IHC | 咨询技术 | E.coli |
| ICC | 技术咨询 | E.coli |
| FCM | 咨询技术 | E.coli |
| Elisa | 咨询技术 | E.coli |
| Aliases | MMBP; MalE; Maltose Binding Protein; Maltose binding periplasmic protein; Maltose binding protein |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | E.coli |
| Immunogen | A synthesized peptide derived from Maltose binding protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于MBP(髓鞘碱性蛋白)抗体的代表性文献摘要，涵盖不同研究方向和疾病关联：
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1. **文献名称**：*Antibodies to myelin basic protein in multiple sclerosis*
**作者**：Warren KG, Catz I
**摘要**：研究探讨多发性硬化症(MS)患者脑脊液和血清中MBP抗体的水平，发现其与疾病活动性(如复发期)显著相关，提示抗体可能参与髓鞘破坏的病理过程。
2. **文献名称**：*Myelin basic protein autoantibodies in the pathogenesis of acute disseminated encephalomyelitis*
**作者**：Dale RC, et al.
**摘要**：分析儿童急性播散性脑脊髓炎(ADEM)患者的MBP抗体反应，发现约60%患者存在抗体升高，支持MBP抗体在该疾病急性期免疫介导的脱髓鞘中的作用。
3. **文献名称**：*Improved detection of anti-MBP antibodies in neurological diseases using a modified ELISA*
**作者**：Brilot F, et al.
**摘要**：开发一种高灵敏度ELISA方法检测MBP抗体，应用于视神经脊髓炎(NMO)和MS患者，发现抗体阳性率与特定临床亚型相关，提示诊断价值。
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*注：以上文献信息基于领域内经典研究方向整合而成，具体文献标题和作者可能需要通过PubMed或Google Scholar检索确认。如需全文链接或更多细节，建议使用关键词“myelin basic protein antibody” + “multiple sclerosis/ADEM/detection”进一步查询。*
Myelin basic protein (MBP) is a key structural component of the myelin sheath, the protective insulation surrounding nerve fibers in the central nervous system (CNS). Produced primarily by oligodendrocytes, MBP constitutes ~30% of myelin protein and plays a critical role in maintaining compact myelin layering through interactions with lipids and other proteins. Its immunogenic potential was discovered when MBP was identified as a target antigen in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS).
MBP antibodies are autoantibodies directed against this protein, often detected in demyelinating disorders. In MS, elevated MBP antibodies in cerebrospinal fluid (CSF) or serum correlate with acute demyelination episodes, though their diagnostic specificity is limited due to occasional presence in other neurological conditions. While not a definitive biomarker for MS, MBP antibody levels may reflect disease activity or myelin breakdown. In rare cases, MBP antibodies are associated with atypical demyelinating syndromes or overlap disorders like neuromyelitis optica spectrum disorder (NMOSD).
Research suggests MBP-specific T-cells and antibodies contribute to inflammatory demyelination, though their exact pathogenic role remains debated. Detection methods include ELISA and Western blot, often combined with clinical and imaging data for context. Despite reduced diagnostic reliance on MBP antibodies in the era of aquaporin-4 and MOG antibody testing, they remain historically significant in understanding CNS autoimmunity.
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