| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag; MA387; MIF; MRP8; NIF; P8;;S100A8 |
| WB Predicted band size | 11 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human S100A8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下为3条关于MRP8(S100A8)抗体的参考文献及其摘要内容概括：
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1. **文献名称**：*"The pro-inflammatory protein S100A8 alters mitochondrial metabolism in neutrophils via TLR4 signaling"*
**作者**：H. Wang et al.
**摘要**：研究利用MRP8特异性抗体，证明S100A8通过TLR4信号通路激活中性粒细胞的线粒体代谢重编程，促进炎症反应，为靶向MRP8的抗炎治疗提供依据。
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2. **文献名称**：*"MRP8/14 as a biomarker in rheumatoid arthritis: antibody-based detection in serum correlates with disease activity"*
**作者**：K. Hammer et al.
**摘要**：通过ELISA和免疫印迹法(使用抗MRP8/14抗体)，验证了血清MRP8/14复合物水平与类风湿关节炎疾病活动的相关性，提出其作为临床监测标志物的潜力。
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3. **文献名称**：*"Targeting MRP8 in colorectal cancer: Antibody-mediated inhibition suppresses tumor growth and metastasis"*
**作者**：J. Li et al.
**摘要**：研究利用抗MRP8单克隆抗体阻断结直肠癌细胞中S100A8的功能，发现其可抑制肿瘤生长和转移，揭示了MRP8在肿瘤微环境中的促癌机制。
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以上文献涵盖MRP8抗体在炎症机制、疾病标志物筛选及肿瘤治疗中的应用。如需扩展，可进一步检索近年发表的免疫学或肿瘤学相关研究。
MRP8 antibody targets myeloid-related protein 8 (MRP8), also known as S100A8. a calcium-binding protein belonging to the S100 family. MRP8 typically forms a heterodimer with MRP14 (S100A9), collectively termed calprotectin, which plays a critical role in innate immunity. This protein is predominantly expressed in neutrophils, monocytes, and macrophages, and its secretion is upregulated during inflammatory responses, infections, or tissue damage. MRP8 functions as a damage-associated molecular pattern (DAMP) molecule, modulating immune cell recruitment, phagocytosis, and inflammation by interacting with receptors like Toll-like receptor 4 (TLR4) or the receptor for advanced glycation end products (RAGE).
MRP8 antibodies are widely used in research to study its involvement in inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease), cancer progression (e.g., leukemia, colorectal cancer), and metabolic disorders. Elevated MRP8 levels correlate with disease severity, making it a potential biomarker for diagnosis or therapeutic monitoring. Additionally, MRP8 antibodies aid in immunohistochemistry, flow cytometry, and Western blotting to localize and quantify protein expression in tissues or fluids. Recent studies also explore its role in neutrophil extracellular traps (NETs) and autoimmune pathologies, highlighting its dual role in promoting resolution or exacerbating chronic inflammation. Understanding MRP8 dynamics through antibody-based assays remains pivotal for developing targeted therapies.
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