| WB | 咨询技术 | Human,Mouse,Rat |
| IF | ChIP:1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ERG;erg-3;p55;KCNH2;;ERG |
| WB Predicted band size | Calculated MW: 54 kDa ; Observed MW: 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human ERG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于ERG抗体的代表性文献摘要：
1. **《Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer》**
- 作者：Tomlins SA, et al.
- 期刊：Science (2005)
- 摘要：首次报道前列腺癌中TMPRSS2-ERG基因融合的高频率现象，推动ERG抗体成为检测该分子标志物的关键工具，为前列腺癌分子分型奠定基础。
2. **《ERG immunohistochemistry as a companion diagnostic for detecting TMPRSS2-ERG gene fusion in prostate cancer》**
- 作者：Park K, et al.
- 期刊：Am J Surg Pathol (2010)
- 摘要：验证ERG抗体的特异性与敏感性，证实其能可靠识别TMPRSS2-ERG融合蛋白，为前列腺癌病理诊断提供高效替代方案。
3. **《ERG expression in prostate cancer: biological role and clinical implications》**
- 作者：Mertz KD, et al.
- 期刊：Cancer Res (2008)
- 摘要：探讨ERG过表达与前列腺癌侵袭性及预后的关联，提示ERG抗体在预测肿瘤进展和临床决策中的潜在应用价值。
注：上述文献为早期经典研究，近年可能有更深入的机制或应用进展，建议通过PubMed或Google Scholar检索关键词“ERG antibody prostate cancer”获取最新成果。
ERG antibodies are immunological tools used to detect the ERG protein, a member of the ETS family of transcription factors encoded by the *ERG* gene. The ERG protein plays critical roles in endothelial cell differentiation, angiogenesis, and hematopoietic development. It regulates genes involved in cell proliferation, apoptosis, and vascular remodeling. In pathology, ERG expression is closely associated with certain cancers, notably prostate cancer and vascular tumors.
In prostate cancer, ERG overexpression is frequently driven by a chromosomal translocation fusing the *TMPRSS2* promoter with the *ERG* gene (TMPRSS2-ERG), observed in approximately 50% of cases. ERG immunohistochemistry (IHC) is thus widely used as a diagnostic marker to confirm prostatic adenocarcinoma and distinguish it from other malignancies. In vascular tumors, ERG is a sensitive marker for endothelial differentiation, aiding in the diagnosis of angiosarcoma and epithelioid hemangioendothelioma.
ERG antibodies are also utilized in research to study vascular biology, tumorigenesis, and mechanisms of gene regulation. Their specificity and reliability make them valuable in both diagnostic pathology and experimental studies. However, interpretation requires caution, as ERG can be expressed in non-neoplastic endothelial cells and non-vascular tumors like Ewing sarcoma. Despite this, ERG remains a pivotal biomarker in understanding and managing cancers with ETS-family gene aberrations.
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