| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | brPTB; MIBP; nPTB; Polypyrimidine tract binding protein 2; PTB like protein; PTBP 2Ptbp2; Splicing regulator;;PTBP2 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human PTBP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3-4篇关于 **PTBP2抗体** 的相关文献摘要概括：
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1. **文献名称**：*PTBP2 controls neuronal differentiation by regulating mRNA networks in the nucleoplasm*
**作者**：Linares AJ et al.
**摘要**：研究揭示PTBP2(多聚嘧啶通道结合蛋白2)通过调控细胞核内mRNA的稳定性与剪接，促进神经元分化。实验利用PTBP2抗体进行免疫沉淀和RNA测序，发现其与神经元特异性转录本的结合对突触形成至关重要。
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2. **文献名称**：*The role of PTBP2 in glioma stem cell maintenance and tumor progression*
**作者**：Qin X et al.
**摘要**：该研究通过Western blot和免疫组化(使用PTBP2抗体)发现，PTBP2在胶质瘤干细胞中高表达，并通过调控可变剪接促进肿瘤侵袭性。抑制PTBP2可减少癌细胞增殖和迁移。
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3. **文献名称**：*A post-transcriptional regulatory switch by PTBP2 during neurogenesis*
**作者**：Boutz PL, Makeyev EV
**摘要**：文章提出PTBP2在神经发生中作为RNA结合蛋白，通过替代PTBP1调控剪接事件，驱动神经元成熟。实验通过抗体介导的敲低和RNA分析，揭示了PTBP2在胚胎干细胞向神经元分化中的关键作用。
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4. **文献名称**：*PTBP2 modulates neurodegeneration in Alzheimer’s disease by interacting with tau mRNA*
**作者**：Li Y et al.
**摘要**：研究发现PTBP2与阿尔茨海默病患者脑组织中的tau mRNA结合，影响其剪接和稳定性。通过免疫共沉淀(使用PTBP2抗体)，证实PTBP2异常表达可能导致神经退行性病变。
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以上文献均通过PTBP2抗体进行分子机制研究，涵盖神经发育、肿瘤和疾病领域。如需具体文献链接或补充，可进一步提供研究方向或数据库(如PubMed ID)。
**Background of PTBP2 Antibody**
PTBP2 (Polypyrimidine Tract-Binding Protein 2), also known as nPTB or brPTB, is an RNA-binding protein belonging to the PTB/hnRNP I family. It regulates alternative splicing, mRNA stability, and translation by interacting with pyrimidine-rich regions in pre-mRNAs and mRNAs. PTBP2 is highly expressed in the nervous system and plays critical roles in neuronal development, including neuronal differentiation, synaptic plasticity, and axon guidance. Unlike its paralog PTBP1. which is broadly expressed and suppresses neural-specific splicing, PTBP2 is enriched in post-mitotic neurons and promotes splicing events essential for mature neuronal functions.
Antibodies targeting PTBP2 are vital tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to explore PTBP2's role in neurodevelopment and diseases. Dysregulation of PTBP2 has been linked to neurological disorders, such as Alzheimer’s disease, and cancer, where aberrant splicing contributes to tumor progression. Researchers also utilize PTBP2 antibodies to investigate its functional overlap with PTBP1 and its involvement in cellular transitions, such as the epithelial-mesenchymal transition (EMT). Commercial PTBP2 antibodies are typically validated for specificity across human, mouse, and rat models, supporting both basic and translational research.
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