| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/250 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human LSP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于LSP1抗体的相关文献信息，按文献名称、作者和摘要内容简要概括：
1. **文献名称**：*LSP1 modulates leukocyte adhesion in flow through CD44 and ERM proteins*
**作者**：Li Y. et al.
**摘要**：该研究揭示了LSP1蛋白通过调控CD44和Ezrin/Radixin/Moesin(ERM)家族蛋白的相互作用，影响中性粒细胞在炎症条件下的黏附与迁移，并利用特异性抗体验证了LSP1在细胞骨架重组中的功能。
2. **文献名称**：*LSP1 antibody-based targeting of tumor-associated macrophages in breast cancer*
**作者**：Smith J.R. & Wang H.
**摘要**：研究开发了一种靶向LSP1的单克隆抗体，通过阻断肿瘤相关巨噬细胞(TAMs)中的LSP1信号通路，抑制肿瘤微环境中的免疫抑制效应，为乳腺癌免疫治疗提供了新策略。
3. **文献名称**：*LSP1 regulates B cell receptor signaling and autoimmunity*
**作者**：Kurosaki T. et al.
**摘要**：通过LSP1基因敲除模型及抗体标记技术，发现LSP1在B细胞受体(BCR)信号传导中起负调控作用，其缺失会导致B细胞过度活化并诱发自身免疫性疾病，揭示了LSP1在免疫稳态中的关键角色。
(注：以上文献为虚拟示例，实际引用时需核实真实论文信息。)
**Background of LSP1 Antibody**
Leukocyte-Specific Protein 1 (LSP1), also known as WP34 or S37. is a cytoskeleton-associated protein predominantly expressed in immune cells, including neutrophils, macrophages, B cells, and T cells. It plays a critical role in regulating cell motility, adhesion, and migration by interacting with F-actin and signaling molecules involved in cytoskeletal reorganization. LSP1 contains multiple phosphorylation sites and structural domains, such as the Src homology 3 (SH3)-binding motifs, enabling its participation in intracellular signaling pathways triggered by chemokines, cytokines, or integrin activation.
LSP1 antibodies are essential tools for studying immune cell behavior and inflammatory responses. They are widely used in techniques like Western blotting, immunofluorescence, and flow cytometry to detect LSP1 expression, localization, and post-translational modifications. Research has linked LSP1 dysfunction to pathological conditions, such as chronic inflammatory diseases, immunodeficiency disorders, and cancer metastasis, highlighting its role in modulating immune cell infiltration and tumor microenvironment interactions.
In mouse models, LSP1 knockout studies reveal impaired neutrophil chemotaxis and reduced immune cell recruitment to infection sites, underscoring its importance in host defense. Commercially available LSP1 antibodies are often validated across species (human, mouse, rat) to support translational research, aiding in the exploration of LSP1's dual roles in pro-inflammatory and anti-tumor immunity.
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