| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Purified recombinant fragment of human HSPA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HSPA2抗体的3篇参考文献示例(文献内容为虚构，仅供格式参考)：
1. **文献名称**: "HSPA2 Expression in Human Testis: Role in Spermatogenesis"
**作者**: Smith A, et al.
**摘要**: 本研究利用HSPA2特异性抗体，通过免疫组化技术揭示了HSPA2蛋白在人类睾丸生精细胞中的高表达，并证实其在精子发生过程中调控减数分裂的关键作用。
2. **文献名称**: "HSPA2 as a Biomarker in Breast Cancer Progression"
**作者**: Lee B, et al.
**摘要**: 通过Western blot和免疫荧光实验(使用HSPA2单克隆抗体)，作者发现HSPA2在乳腺癌组织中的异常高表达与肿瘤转移和化疗耐药性显著相关。
3. **文献名称**: "HSPA2-Mediated Stress Response in Neurodegenerative Diseases"
**作者**: Garcia R, et al.
**摘要**: 该研究采用HSPA2多克隆抗体分析阿尔茨海默病患者脑组织，发现HSPA2通过调节错误折叠蛋白清除途径延缓神经元退化，提示其潜在治疗价值。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词"HSPA2 antibody application"或"HSPA2 immunodetection"。
**Background of HSPA2 Antibody**
HSPA2. a member of the heat shock protein 70 (HSP70) family, functions as a molecular chaperone involved in protein folding, cellular stress response, and maintenance of proteostasis. It is encoded by the *HSPA2* gene and shares structural homology with other HSP70 proteins, featuring a conserved N-terminal ATPase domain and a C-terminal substrate-binding domain. Unlike its constitutive counterpart HSPA8. HSPA2 exhibits tissue-specific expression, prominently in the testes, where it plays a critical role in spermatogenesis, particularly during meiosis and sperm maturation. It also contributes to stress adaptation in somatic cells under pathological conditions, such as cancer or neurodegeneration.
HSPA2 antibodies are essential tools for studying its expression, localization, and functional roles. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate HSPA2's involvement in diseases. For instance, elevated HSPA2 levels are observed in certain cancers (e.g., breast, lung), correlating with tumor progression and therapy resistance, making it a potential biomarker or therapeutic target. In reproductive biology, HSPA2 antibodies help assess male infertility linked to defective sperm development.
Commercial HSPA2 antibodies are typically raised against specific epitopes, with monoclonal antibodies offering high specificity and polyclonal antibodies providing broader detection. Validation across applications and species (human, mouse, rat) ensures reliability. Ongoing research focuses on elucidating HSPA2's dual roles in cellular stress and disease mechanisms, underscoring its relevance in both basic and clinical contexts.
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