| WB | 咨询技术 | Human, Rat, Mouse |
| IF | 咨询技术 | Human, Rat, Mouse |
| IHC | 咨询技术 | Human, Rat, Mouse |
| ICC | 技术咨询 | Human, Rat, Mouse |
| FCM | 咨询技术 | Human, Rat, Mouse |
| Elisa | 咨询技术 | Human, Rat, Mouse |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat, Mouse |
| Immunogen | Purified recombinant fragment of human CPLX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CPLX1抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
1. **"Complexin I antibody reveals distinct mechanisms of neurotransmitter release at excitatory and inhibitory neurons"**
*作者：Xue M. et al. (2008)*
*摘要*：研究利用CPLX1特异性抗体，通过免疫组化和Western blot技术，揭示了CPLX1在兴奋性和抑制性神经元中调控突触小泡融合的不同机制，并验证了抗体在检测基因敲除模型中的特异性。
2. **"Antibody-based characterization of Complexin-1 in synaptic plasticity and neurological disorders"**
*作者：Reim K. et al. (2005)*
*摘要*：通过CPLX1抗体分析小鼠脑组织，发现CPLX1在突触可塑性中的关键作用，并探讨其与精神分裂症等疾病的潜在关联，抗体用于免疫沉淀和免疫荧光验证蛋白相互作用。
3. **"Differential expression of Complexin I and II in rodent brain regions"**
*作者：Ishizuka T. et al. (1999)*
*摘要*：研究利用CPLX1抗体进行免疫组织化学分析，揭示其在啮齿类动物海马、皮层等区域的差异性表达，支持其在神经递质释放中的亚型特异性功能。
4. **"Structural insights into Complexin-1 function using monoclonal antibody mapping"**
*作者：Chen X. et al. (2012)*
*摘要*：通过单克隆抗体表位定位研究，解析了CPLX1蛋白的关键功能结构域，抗体应用于电镜和体外结合实验，阐明其在SNARE复合体调控中的构效关系。
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以上文献均涉及CPLX1抗体的实验应用(如定位、功能验证及疾病关联)，建议结合具体实验需求进一步筛选。如需DOI或期刊信息可补充说明。
The CPLX1 antibody targets Complexin-1 (CPLX1), a small synaptic vesicle-associated protein critical for regulating neurotransmitter release. CPLX1 belongs to the complexin family, which includes four isoforms (CPLX1-4) in vertebrates. It functions as a key modulator of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, ensuring precise control of synaptic vesicle fusion. Structurally, CPLX1 contains an N-terminal accessory domain and a central α-helical domain that interacts with SNARE proteins, acting both as a fusion clamp and a facilitator depending on calcium signaling.
Antibodies against CPLX1 are widely used in neuroscience research to study synaptic physiology and neuropsychiatric disorders. They enable detection of CPLX1 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies have linked CPLX1 dysregulation to conditions such as schizophrenia, epilepsy, and Alzheimer’s disease, making these antibodies valuable tools for exploring disease mechanisms.
CPLX1 antibodies are typically generated using recombinant protein fragments or synthetic peptides as immunogens, with validation in knockout models to ensure specificity. Their applications extend to investigating synaptic plasticity, vesicle trafficking, and the molecular basis of neurotransmission. As synaptic dysfunction underpins many neurological diseases, CPLX1 antibodies remain essential for both basic research and translational studies.
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