| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human DCTN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于DCTN2抗体的3篇参考文献及其摘要内容(注：文献为模拟示例，实际引用需核实)：
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1. **标题**: *DCTN2 (dynamitin) is essential for mitotic progression in human cells*
**作者**: Smith A, et al.
**摘要**: 本研究利用DCTN2特异性抗体，通过免疫荧光和Western blot分析，发现DCTN2在有丝分裂中调控染色体分离。敲低DCTN2导致纺锤体异常和细胞周期停滞，表明其在维持基因组稳定性中的关键作用。
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2. **标题**: *DCTN2 dysfunction disrupts axonal transport and links to neurodegenerative pathology*
**作者**: Chen L, et al.
**摘要**: 通过DCTN2抗体标记小鼠神经元，发现DCTN2缺失导致轴突运输障碍，引发Tau蛋白异常聚集。结果提示DCTN2缺陷可能与阿尔茨海默病等神经退行性疾病的病理机制相关。
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3. **标题**: *DCTN2 interacts with viral capsid proteins to promote intracellular trafficking*
**作者**: Kimura H, et al.
**摘要**: 使用DCTN2抗体进行免疫共沉淀实验，发现DCTN2与多种病毒衣壳蛋白结合，调控病毒颗粒的细胞内运输。研究为抗病毒药物靶点开发提供了新方向。
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如需具体文献，建议通过PubMed或Google Scholar以"DCTN2 antibody"+"functional study"等关键词检索，并筛选近年高影响力期刊论文。
The DCTN2 antibody targets the DCTN2 (Dynactin subunit 2) protein, a critical component of the dynactin complex, which interacts with cytoplasmic dynein to regulate microtubule-based intracellular transport. DCTN2. also known as p50 or dynamitin, plays a key role in stabilizing the dynactin structure and mediating cargo binding, ensuring proper organelle positioning, vesicle trafficking, and mitotic spindle organization. Dysregulation of DCTN2 is linked to neurodegenerative diseases (e.g., ALS, Parkinson’s) and cancers due to disrupted cellular transport mechanisms.
DCTN2 antibodies are widely used in research to study protein localization, expression levels, and functional interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate DCTN2's role in cellular processes, such as neuronal axonal transport and cell division, and its association with disease pathways. Commercial DCTN2 antibodies are typically raised in rabbits or mice, validated for specificity and sensitivity. Recent studies also explore DCTN2 as a potential biomarker or therapeutic target, emphasizing its importance in maintaining cellular homeostasis and disease pathology.
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