| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PDZRN4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3-4条关于PDZRN4抗体的参考文献(虚构示例，供参考)：
1. **文献名称**：*PDZRN4 regulates synaptic ubiquitination and neuronal development*
**作者**：Smith A, et al.
**摘要**：通过Western blot和免疫荧光技术，使用PDZRN4特异性抗体证实其在神经元突触中的表达，并揭示其通过泛素化修饰调控突触蛋白稳定性。
2. **文献名称**：*PDZRN4 modulates muscle atrophy via TGF-β signaling*
**作者**：Chen L, et al.
**摘要**：利用PDZRN4抗体进行免疫组化分析，发现PDZRN4在肌肉萎缩模型中表达上调，并通过调控TGF-β通路影响肌细胞分化。
3. **文献名称**：*PDZRN4 interaction network in cancer progression*
**作者**：Wang Y, et al.
**摘要**：通过免疫共沉淀结合质谱分析，鉴定PDZRN4在乳腺癌细胞中的相互作用蛋白，抗体验证其与E3泛素连接酶复合物的关联。
4. **文献名称**：*Developmental expression profile of PDZRN4 in murine tissues*
**作者**：Kimura T, et al.
**摘要**：采用PDZRN4多克隆抗体进行组织免疫染色，系统描述其在小鼠胚胎发育不同阶段的表达模式，提示其在神经和肌肉发育中的潜在作用。
(注：以上文献为模拟示例，实际研究中请通过PubMed或Google Scholar以关键词“PDZRN4 antibody”+“Western blot/immunohistochemistry”检索真实文献。)
The PDZRN4 (PDZ Domain-Containing RING Finger 4) protein, also known as LNX4. is a member of the LNX family of E3 ubiquitin ligases. It contains an N-terminal RING domain, which mediates ubiquitination, and multiple C-terminal PDZ domains that facilitate protein-protein interactions. PDZRN4 is implicated in regulating cellular processes such as protein degradation, signal transduction, and tissue development, particularly in neuromuscular systems. Studies suggest its involvement in ubiquitination-dependent modulation of pathways like Notch and Wnt, as well as roles in myogenesis and synaptic organization.
PDZRN4 antibodies are immunological tools designed to detect and study the expression, localization, and function of the PDZRN4 protein. These antibodies are typically produced in hosts like rabbits or mice using immunogenic epitopes derived from PDZRN4's conserved regions. Validated applications include Western blotting, immunohistochemistry, and immunoprecipitation. Researchers employ PDZRN4 antibodies to investigate its interaction partners, tissue-specific expression patterns (e.g., in brain, muscle, and testis), and dysregulation in pathological contexts such as cancer or neurodegenerative diseases. Reliable antibodies are critical for elucidating PDZRN4's role in cellular homeostasis and disease mechanisms.
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