| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/250 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human BABAM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于BABAM1抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*BABAM1 regulates the stability and function of the BRCA1-BRCA2-PALB2 complex in DNA repair*
**作者**：Hu Y. et al.
**摘要**：该研究利用BABAM1特异性抗体，通过免疫共沉淀和蛋白质印迹技术，揭示了BABAM1在维持BRCA1复合体稳定性中的作用，并证明其缺失导致DNA同源重组修复缺陷，增加细胞对放疗的敏感性。
2. **文献名称**：*BABAM1 interacts with the BRISC deubiquitinase complex to regulate inflammatory signaling*
**作者**：Sato Y. et al.
**摘要**：研究通过免疫荧光和Western blot技术，结合BABAM1抗体，发现BABAM1与去泛素化酶复合体BRISC相互作用，调控炎症相关信号通路(如NF-κB)，为自身免疫疾病治疗提供潜在靶点。
3. **文献名称**：*The role of BABAM1 in breast cancer progression and its clinical implications*
**作者**：Wang L. et al.
**摘要**：通过免疫组织化学(IHC)分析乳腺癌组织样本，发现BABAM1表达水平与患者预后显著相关，低表达患者总生存期较短，提示BABAM1可能作为乳腺癌的生物标志物。
这些文献展示了BABAM1抗体在机制研究(DNA修复、炎症调控)及临床转化(癌症预后评估)中的关键应用。
**Background of BABAM1 Antibody**
BABAM1 (BRISC and BRCA1-A complex member 1), also known as CCDC98 or BRE, is a multifunctional protein implicated in DNA damage response, cell cycle regulation, and immune signaling. It serves as a critical component of two distinct complexes: the BRCA1-A complex, which facilitates DNA repair through homologous recombination by deubiquitinating γ-H2AX, and the BRISC complex, which regulates inflammatory signaling by modulating type I interferon and NF-κB pathways.
BABAM1 antibodies are valuable tools for studying its role in maintaining genomic stability and its association with diseases. Research highlights BABAM1's interaction with BRCA1. linking it to breast and ovarian cancers, particularly in individuals with BRCA1 mutations. Additionally, BRISC-associated BABAM1 has been implicated in autoimmune disorders and chronic inflammation, emphasizing its dual context-dependent functions.
Antibodies targeting BABAM1 are used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to analyze expression levels, subcellular localization, and protein-protein interactions. Studies utilizing these antibodies have revealed BABAM1's modular structure, including tandem BRCA1-binding domains and coiled-coil regions essential for complex assembly.
Overall, BABAM1 antibodies advance understanding of its contributions to cancer biology, immune regulation, and potential therapeutic targeting, making them crucial for both basic research and clinical applications.
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