| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CLTCL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与CLTCL1抗体相关的文献摘要概括(注：文献为模拟示例，实际文献需通过学术数据库检索)：
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1. **文献名称**：CLTCL1 regulates endosomal cholesterol trafficking in neurodegenerative diseases
**作者**：Smith J, et al.
**摘要**：研究利用CLTCL1抗体进行免疫荧光和Western blot分析，发现CLTCL1通过与网格蛋白复合体相互作用调控晚期内吞体中的胆固醇运输，其表达异常与阿尔茨海默病模型中的神经元脂质沉积相关。
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2. **文献名称**：CLTCL1 as a novel biomarker in lung adenocarcinoma progression
**作者**：Li X, et al.
**摘要**：通过CLTCL1特异性抗体进行免疫组化分析，发现CLTCL1在肺癌组织中的高表达与患者不良预后相关，其可能通过促进EGFR内吞和下游信号通路激活驱动肿瘤侵袭。
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3. **文献名称**：Functional characterization of CLTCL1 in clathrin-mediated endocytosis
**作者**：Garcia-Ruiz S, et al.
**摘要**：利用CRISPR敲除细胞系和CLTCL1抗体验证，证明CLTCL1在非经典网格蛋白包被囊泡形成中起关键作用，尤其在神经元突触膜蛋白的循环过程中具有独特功能。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“CLTCL1 antibody” + 研究领域(如癌症、神经科学等)。实际文献可能聚焦于抗体验证、蛋白定位或疾病机制研究。
The CLTCL1 (Clathrin Heavy Chain Like 1) antibody is a tool used to study the CLTCL1 protein, encoded by the CLTCL1 gene in humans. CLTCL1 is a paralog of CLTC (Clathrin Heavy Chain) and shares structural homology with clathrin heavy chains, which are critical components of clathrin-coated vesicles involved in intracellular trafficking, endocytosis, and membrane remodeling. Unlike the ubiquitously expressed CLTC, CLTCL1 (also termed CHC22) exhibits tissue-specific expression, with higher levels in skeletal muscle, pancreas, and brain. It plays distinct roles in glucose transporter GLUT4 vesicle trafficking in muscle and fat cells, as well as in neuronal function. CLTCL1's unique trafficking pathways are implicated in metabolic regulation and cellular adaptation to energy demands.
CLTCL1 antibodies are primarily used in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies utilizing these antibodies have revealed CLTCL1's involvement in diseases such as diabetes, myopathies, and neurodegenerative disorders. For example, altered CLTCL1 expression has been linked to insulin resistance and impaired GLUT4 storage. Additionally, CLTCL1 polymorphisms are associated with neurodevelopmental conditions. Commercial CLTCL1 antibodies are typically raised in rabbits or mice, targeting specific epitopes within its N-terminal or C-terminal domains. Validation includes testing for cross-reactivity with CLTC to ensure specificity. Ongoing research aims to clarify CLTCL1's regulatory mechanisms and therapeutic potential, highlighting its growing importance in cellular and disease biology.
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