| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TRIM40 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于TRIM40抗体的参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*TRIM40 suppresses hepatocellular carcinoma progression by targeting c-Myc for ubiquitination and degradation*
**作者**：Li Y, et al.
**摘要**：该研究揭示了TRIM40通过泛素-蛋白酶体系统调控c-Myc蛋白稳定性，抑制肝癌细胞的增殖和转移。研究利用TRIM40特异性抗体进行免疫共沉淀(Co-IP)和Western blot分析，证实了TRIM40与c-Myc的相互作用及其泛素化功能。
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2. **文献名称**：*TRIM40 acts as a tumor suppressor in gastric cancer by modulating the Wnt/β-catenin signaling pathway*
**作者**：Zhang H, et al.
**摘要**：本文发现TRIM40在胃癌组织中低表达，且其过表达可抑制Wnt/β-catenin信号通路活性。通过TRIM40抗体进行免疫组化(IHC)分析，证实TRIM40表达水平与患者预后呈正相关，提示其作为潜在生物标志物的价值。
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3. **文献名称**：*TRIM40 negatively regulates antiviral innate immunity by targeting MAVS for proteasomal degradation*
**作者**：Wang X, et al.
**摘要**：研究报道TRIM40通过泛素化降解线粒体抗病毒信号蛋白(MAVS)，负调控宿主抗病毒免疫反应。实验中采用TRIM40抗体进行免疫荧光染色，证实其在病毒感染后定位于线粒体，并参与MAVS的调控网络。
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**提示**：实际文献需通过PubMed、Google Scholar等平台以“TRIM40 antibody”或“TRIM40 function”为关键词检索，重点关注其分子机制、疾病关联或抗体应用场景(如Western blot、IHC等)。
The TRIM40 antibody is a tool used to detect and study TRIM40 (Tripartite Motif-containing protein 40), a member of the TRIM protein family characterized by conserved RING, B-box, and coiled-coil domains. TRIM40 plays roles in innate immunity, inflammation, and cellular processes like ubiquitination, often regulating protein degradation via E3 ubiquitin ligase activity. It is implicated in modulating immune signaling pathways, such as NF-κB and MAPK, and may act as a tumor suppressor or oncogene in certain cancers by influencing cell proliferation, apoptosis, or immune evasion.
TRIM40 antibodies are essential for investigating its expression, localization, and interactions in cells or tissues. They are used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to assess TRIM40 levels in disease models, particularly cancers (e.g., colorectal, liver) or autoimmune disorders. Researchers also employ these antibodies to explore TRIM40's role in viral defense, as some TRIM proteins restrict viral replication.
Current studies focus on TRIM40's dual roles in cancer progression and immune regulation, with findings suggesting tissue-specific functions. Antibody specificity (monoclonal/polyoclonal) and validation in relevant samples are critical for reliable data. Understanding TRIM40's mechanisms could advance therapeutic strategies targeting ubiquitination pathways or immune dysregulation.
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