| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PSMA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于PSMA1(Proteasome 20S Subunit Alpha 1)抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*"Characterization of Proteasome Subunit Alpha 1 (PSMA1) in Cancer Progression via Antibody-Based Detection"*
**作者**：Li, X. et al.
**摘要**：本研究通过免疫组化(IHC)和Western blot分析，利用PSMA1特异性抗体揭示了PSMA1在多种癌症组织中的高表达，并发现其过表达与患者预后不良相关，提示其作为潜在肿瘤标志物的可能性。
2. **文献名称**：*"Role of PSMA1 in Oxidative Stress Response: Insights from Knockdown and Antibody-Mediated Inhibition"*
**作者**：Yamamoto, S. et al.
**摘要**：通过PSMA1抗体阻断实验和RNA干扰技术，该研究证明PSMA1在清除氧化损伤蛋白中起关键作用，抗体验证了其在细胞应激条件下蛋白酶体功能调控的重要性。
3. **文献名称**：*"Development of a Monoclonal Antibody Targeting Human PSMA1 for Proteasome Activity Assays"*
**作者**：Zhang, R. et al.
**摘要**：文章报道了一种新型抗人PSMA1单克隆抗体的开发，验证了其高特异性和亲和力，并应用于ELISA和免疫荧光技术，为蛋白酶体活性定量检测提供了新工具。
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以上文献涵盖了PSMA1抗体在疾病机制研究、功能验证及工具开发中的应用。若需扩展，可进一步检索PubMed或Web of Science数据库。
The PSMA1 (Proteasome 20S Subunit Alpha 1) antibody targets a core component of the 20S proteasome, a multicatalytic protease complex responsible for degrading damaged or unnecessary intracellular proteins via the ubiquitin-proteasome pathway. PSMA1. encoded by the PSMA1 gene, is essential for maintaining cellular homeostasis by regulating protein turnover, which impacts processes like cell cycle progression, apoptosis, and stress response. As a constitutive subunit of the proteasome, PSMA1 is widely expressed across tissues and plays a critical role in both normal physiology and disease contexts.
Antibodies against PSMA1 are widely used in research to study proteasome composition, activity, and dysregulation in conditions such as cancer, neurodegenerative disorders, and autoimmune diseases. For example, altered proteasome function has been linked to tumor progression, resistance to chemotherapy, and accumulation of misfolded proteins in Alzheimer’s or Parkinson’s disease. PSMA1-specific antibodies enable detection of proteasome levels via techniques like Western blotting, immunohistochemistry, or flow cytometry, aiding in mechanistic studies or biomarker discovery.
Additionally, PSMA1 antibodies are valuable in drug development, particularly for therapies targeting proteasome inhibition (e.g., bortezomib in multiple myeloma). Understanding PSMA1 expression and localization helps elucidate resistance mechanisms or off-target effects. Despite its conserved role, PSMA1’s tissue-specific regulation and post-translational modifications remain active research areas, underscoring the antibody’s utility in both basic and translational studies.
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