| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PRKCD |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于PRKCD抗体的模拟参考文献示例(仅供参考，实际文献需通过学术数据库检索)：
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1. **文献名称**：*PRKCD modulates oxidative stress-induced apoptosis in cardiomyocytes*
**作者**：Chen Y, et al.
**摘要**：研究利用PRKCD抗体通过Western blot和免疫荧光技术，发现PRKCD在心肌细胞氧化应激中调控线粒体依赖性凋亡通路，抑制PRKCD可减轻细胞损伤。
2. **文献名称**：*PRKCD expression correlates with tumor progression in glioblastoma*
**作者**：Wang L, et al.
**摘要**：通过免疫组化分析胶质母细胞瘤组织，PRKCD抗体检测显示其高表达与肿瘤侵袭性和患者预后不良相关，提示PRKCD作为潜在治疗靶点。
3. **文献名称**：*PRKCD regulates B-cell receptor signaling in lupus pathogenesis*
**作者**：Singh RR, et al.
**摘要**：在系统性红斑狼疮模型中，使用PRKCD抗体进行流式细胞术分析，发现PRKCD异常激活导致B细胞过度反应，促进自身抗体产生。
4. **文献名称**：*PRKCD deficiency enhances insulin sensitivity via AMPK pathway*
**作者**：Kim H, et al.
**摘要**：研究通过PRKCD基因敲除小鼠模型及抗体检测，证实PRKCD缺失通过AMPK通路改善胰岛素抵抗，为代谢疾病治疗提供新思路。
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**建议**：如需真实文献，可访问PubMed、Google Scholar等平台，搜索关键词“PRKCD antibody”或“PRKCD + 研究领域(如cancer, apoptosis等)”，筛选目标文章。
The PRKCD antibody is a crucial tool for studying the protein kinase C delta (PKCδ) isoform, a member of the serine/threonine kinase family involved in diverse cellular processes. PKCδ, encoded by the PRKCD gene, plays roles in apoptosis, proliferation, differentiation, and immune regulation. Its structure includes regulatory and catalytic domains, activated by phosphorylation and lipid mediators like diacylglycerol. PRKCD antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to detect protein expression, localization, and post-translational modifications in tissues or cell lines.
Research highlights PKCδ's dual role in cancer—acting as a tumor suppressor by promoting apoptosis in some contexts, while driving proliferation and metastasis in others. It also contributes to neurodegenerative diseases, diabetes, and autoimmune disorders by modulating oxidative stress, inflammation, and cell survival pathways. Dysregulation of PKCδ is linked to chemoresistance and pathological signaling cascades, making it a therapeutic target. PRKCD antibodies help validate experimental models, assess PKCδ activity in drug development, and explore biomarker potential. However, results require careful interpretation due to isoform-specific cross-reactivity or phosphorylation-state variability. Overall, these antibodies are vital for unraveling PKCδ's complex roles in health and disease.
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