| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TRIM7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是假设性的TRIM7抗体相关参考文献示例(仅供参考，实际文献需通过学术数据库检索)：
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1. **文献名称**: "TRIM7 inhibits enterovirus replication through ubiquitination of viral 3D polymerase"
**作者**: Zhang Y, et al.
**摘要**: 本研究利用TRIM7特异性抗体进行Western blot和免疫荧光实验，发现TRIM7通过泛素化修饰肠道病毒3D聚合酶并促进其降解，从而抑制病毒复制，揭示了TRIM7在抗病毒先天免疫中的关键作用。
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2. **文献名称**: "TRIM7 promotes hepatocellular carcinoma progression by stabilizing c-Myc protein"
**作者**: Liu R, et al.
**摘要**: 通过免疫组化(使用TRIM7抗体)分析肝癌组织样本，发现TRIM7高表达与患者预后不良相关。机制研究表明，TRIM7通过结合并抑制c-Myc蛋白泛素化降解，促进肿瘤增殖。
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3. **文献名称**: "TRIM7 negatively regulates NLRP3 inflammasome activation via targeting ASC"
**作者**: Wang X, et al.
**摘要**: 研究采用TRIM7抗体进行共免疫沉淀实验，证实TRIM7与凋亡相关斑点样蛋白(ASC)相互作用，促进其K48链泛素化降解，进而抑制NLRP3炎症小体过度活化，为炎症性疾病治疗提供新靶点。
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4. **文献名称**: "TRIM7 deficiency enhances cancer immunotherapy efficacy by modulating PD-L1 stability"
**作者**: Chen L, et al.
**摘要**: 通过构建TRIM7基因敲除小鼠模型并结合抗体介导的流式细胞术分析，发现TRIM7通过调控PD-L1蛋白稳定性影响肿瘤免疫逃逸，提示靶向TRIM7可增强免疫检查点抑制剂疗效。
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**注意**：以上文献为模拟内容，实际引用请查询PubMed、Web of Science等平台获取真实数据。
The TRIM7 antibody is a research tool designed to detect and study TRIM7 (Tripartite Motif-containing protein 7), a member of the TRIM family of E3 ubiquitin ligases. TRIM proteins play critical roles in innate immunity, antiviral defense, and cellular processes like apoptosis and autophagy. TRIM7. specifically, contains conserved domains—RING, B-box, and coiled-coil—and a C-terminal PRY-SPRY domain, enabling interactions with target proteins. It is implicated in regulating immune signaling pathways, including NF-κB and interferon responses, and has antiviral activity against pathogens like hepatitis C virus (HCV) and enteroviruses by promoting ubiquitination-dependent degradation of viral proteins.
TRIM7 antibodies are used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore its expression, localization, and function in various tissues and disease contexts. Studies suggest TRIM7 may have dual roles in cancer, acting as a tumor suppressor or promoter depending on the context. For example, it is downregulated in hepatocellular carcinoma but overexpressed in breast cancer, correlating with metastasis. These antibodies help researchers investigate TRIM7's involvement in viral infections, cancer progression, and autoimmune disorders, making them vital for understanding its biological and pathological mechanisms. Validation of antibody specificity (e.g., via knockout controls) is essential to ensure reliable experimental outcomes.
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