| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TSPAN4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TSPAN4抗体的3篇示例文献(内容为假设性示例，实际文献需检索数据库确认)：
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1. **文献名称**: *TSPAN4 as a Novel Biomarker in Colorectal Cancer: Expression and Functional Analysis*
**作者**: Smith A, et al.
**摘要**: 研究通过免疫组化验证了TSPAN4抗体在结直肠癌组织中的高表达，并发现其过表达与患者预后不良相关，提示TSPAN4可能作为肿瘤治疗的潜在靶点。
2. **文献名称**: *Role of TSPAN4 in Immune Regulation: Insights from Monoclonal Antibody Blockade*
**作者**: Zhang L, et al.
**摘要**: 利用特异性TSPAN4抗体阻断实验，揭示TSPAN4通过调节T细胞表面受体信号通路影响免疫应答，为自身免疫疾病治疗提供新方向。
3. **文献名称**: *TSPAN4 Antibody-Drug Conjugate Suppresses Tumor Growth in Preclinical Models*
**作者**: Brown K, et al.
**摘要**: 开发了一种靶向TSPAN4的抗体-药物偶联物(ADC)，在体外和体内实验中显著抑制肺癌细胞增殖，证明其作为新型抗癌疗法的潜力。
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**建议**：实际研究中可通过PubMed或Google Scholar以关键词“TSPAN4 antibody”、“TSPAN4 function”检索最新文献，优先选择近5年内发表、高影响因子期刊的研究。
The TSPAN4 antibody is a research tool designed to detect and study tetraspanin-4 (TSPAN4), a member of the tetraspanin family of transmembrane proteins. Tetraspanins are characterized by four transmembrane domains and play roles in cell adhesion, motility, and signal transduction by organizing membrane protein complexes. TSPAN4. also known as NAST6 or TSP-4. is involved in modulating cellular processes such as cell proliferation, differentiation, and tumor progression. It interacts with integrins, growth factor receptors, and other tetraspanins, forming functional networks that influence cancer metastasis, immune responses, and neurological functions.
Antibodies targeting TSPAN4 are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to analyze protein expression, localization, and interactions in various tissues or cell lines. These antibodies are critical for investigating TSPAN4's role in diseases, particularly cancers (e.g., glioblastoma, breast cancer) where its dysregulation is linked to tumor invasiveness. They also aid in studying neurological disorders, as tetraspanins are implicated in synaptic plasticity and neurodegenerative conditions.
Validated TSPAN4 antibodies exhibit high specificity, often confirmed via knockout controls or siRNA-mediated silencing. Commercial variants include monoclonal and polyclonal types, each offering advantages in sensitivity or multiplex assays. Ongoing research explores TSPAN4's potential as a therapeutic target or diagnostic biomarker, underscoring the antibody's importance in both basic and translational biomedical studies.
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