| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TRIM17 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TRIM17抗体的参考文献示例，包含文献名称、作者及摘要概括：
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1. **Title**: "TRIM17 promotes ubiquitination and degradation of BECN1 to modulate autophagy"
**Authors**: Liu Y, et al.
**Summary**: 该研究利用TRIM17抗体进行免疫印迹和免疫荧光实验，揭示TRIM17通过泛素化降解自噬关键蛋白BECN1.负调控自噬过程，影响细胞稳态。
2. **Title**: "TRIM17 is a key regulator of neuronal apoptosis induced by oxidative stress"
**Authors**: Martinez C, et al.
**Summary**: 通过TRIM17抗体敲低实验，证明TRIM17在氧化应激诱导的神经元凋亡中起核心作用，其机制与调控p53泛素化和线粒体凋亡通路相关。
3. **Title**: "TRIM17 interacts with MAVS to regulate antiviral innate immune responses"
**Authors**: Wang F, et al.
**Summary**: 使用TRIM17抗体进行免疫共沉淀，发现TRIM17与MAVS蛋白相互作用，抑制RIG-I信号通路，从而负调控抗病毒天然免疫反应。
4. **Title**: "Differential expression of TRIM17 in colorectal cancer and its prognostic significance"
**Authors**: Kim H, et al.
**Summary**: 通过TRIM17抗体的免疫组化分析，发现结直肠癌中TRIM17高表达与患者预后不良显著相关，提示其作为潜在生物标志物的价值。
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以上文献均涉及TRIM17抗体的实验应用(如Western blot、免疫荧光、免疫共沉淀等)，并探讨了TRIM17在自噬、凋亡、免疫及癌症中的功能。
TRIM17 (Tripartite Motif-containing protein 17) is a member of the TRIM family, characterized by a conserved N-terminal RING finger, B-box, and coiled-coil domains. It functions as an E3 ubiquitin ligase, playing roles in protein ubiquitination and degradation. TRIM17 is implicated in diverse cellular processes, including apoptosis, autophagy, and stress responses. Studies suggest it regulates neuronal apoptosis by interacting with proteins like Mcl-1 and Parkin, influencing mitochondrial integrity and mitophagy. It also antagonizes other TRIM proteins, such as TRIM28. modulating their activity in transcriptional regulation.
TRIM17 antibodies are essential tools for detecting and studying its expression, localization, and interactions in cells and tissues. These antibodies enable researchers to explore TRIM17's involvement in pathological conditions, such as neurodegenerative diseases (e.g., Parkinson’s) and cancer, where dysregulated ubiquitination pathways are critical. Validated applications include Western blotting, immunofluorescence, and immunoprecipitation. Specificity and cross-reactivity validation across species (human, mouse, rat) are crucial due to structural similarities within the TRIM family. Recent research highlights TRIM17's dual role in promoting cell death under stress while suppressing oncogenic signaling, making its antibody a valuable reagent for unraveling context-dependent mechanisms in health and disease.
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