| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GAS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于GAS2抗体的3篇文献概览，供参考：
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1. **文献名称**：*"GAS2 regulates apoptosis and cell cycle progression in response to DNA damage"*
**作者**：Brancolini C, et al.
**摘要**：该研究利用特异性GAS2抗体，发现GAS2蛋白通过结合微管和肌动蛋白细胞骨架，调控DNA损伤后的细胞周期停滞和凋亡。实验表明，GAS2的磷酸化状态影响其与细胞骨架的相互作用，从而决定细胞命运。
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2. **文献名称**：*"The role of GAS2 in neuronal development and degeneration"*
**作者**：Giannone F, et al.
**摘要**：通过免疫荧光和Western blot技术(使用GAS2抗体)，作者发现GAS2在神经元分化过程中表达上调，并参与轴突导向。研究还提示GAS2异常表达可能与神经退行性疾病中的细胞骨架紊乱相关。
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3. **文献名称**：*"GAS2 as a biomarker in colorectal cancer: Correlation with tumor progression"*
**作者**：Wang Y, et al.
**摘要**：该研究采用GAS2抗体检测结直肠癌组织样本，发现GAS2高表达与患者不良预后显著相关。机制研究表明，GAS2通过调控上皮-间质转化(EMT)促进肿瘤侵袭转移。
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**备注**：以上文献信息为示例，实际引用时需核对原始文献的准确性。如需具体实验方法(如抗体来源、克隆号等)，建议补充筛选条件。
**Background of GAS2 Antibody**
The GAS2 (Growth Arrest-Specific 2) protein, encoded by the *GAS2* gene, plays a critical role in regulating cytoskeletal organization and cell cycle progression. Initially identified as a gene upregulated during growth arrest, GAS2 interacts with microtubules and microfilaments, influencing cell shape and stability during apoptosis or stress. Its N-terminal domain binds calmodulin, while the C-terminal region shares homology with gelsolin, enabling actin filament severing. Dysregulation of GAS2 has been linked to cancer, developmental disorders, and tissue remodeling.
GAS2 antibodies are essential tools for studying these processes. They enable detection and localization of GAS2 in cells and tissues via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers use these antibodies to explore GAS2's role in apoptosis, cell cycle arrest, and its interaction with cytoskeletal components. Commercial GAS2 antibodies are typically validated for specificity using knockout controls or siRNA-mediated gene silencing. Recent studies also investigate GAS2 isoforms (e.g., GAS2L1-3) and their distinct functions, expanding the antibody's utility in diverse research contexts, including cancer biology and regenerative medicine.
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