| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GIMAP8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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1. **"GIMAP8 regulates mitochondrial integrity and modulates T-cell survival through interaction with the permeability transition pore complex"**
- **Authors**: A. Müller et al.
- **摘要**: 研究揭示了GIMAP8通过与线粒体通透性转换孔复合体(mPTP)相互作用调控T细胞存活，利用特异性抗体证实其在线粒体膜稳定性中的作用，并发现其缺失导致T细胞凋亡增加。
2. **"Characterization of a novel monoclonal antibody against GIMAP8 for detection of immune cell subpopulations"**
- **Authors**: K. Sato et al.
- **摘要**: 开发了一种针对GIMAP8的单克隆抗体，验证其在流式细胞术和免疫组化中的应用，证明其在人外周血单核细胞(PBMC)中特异性标记特定淋巴细胞亚群。
3. **"GIMAP8 deficiency exacerbates colitis in murine models through dysregulated autophagy"**
- **Authors**: R. Chen & L. Wei
- **摘要**: 利用GIMAP8抗体研究其在肠道炎症中的作用，发现GIMAP8敲除小鼠结肠炎加重，机制与自噬通路异常及促炎细胞因子分泌增加相关。
4. **"The GTPase GIMAP8 interacts with Bcl-2 to inhibit apoptosis in hematopoietic cells"**
- **Authors**: M. Torres et al.
- **摘要**: 通过免疫共沉淀(使用GIMAP8抗体)证实其与Bcl-2的相互作用，揭示GIMAP8通过抑制线粒体凋亡通路维持造血干细胞稳态。
GIMAP8 (GTPase of the immunity-associated protein 8) is a member of the GIMAP family, a group of evolutionary conserved proteins characterized by a GTP-binding domain and roles in immune system regulation. These proteins are predominantly expressed in lymphocytes and are implicated in cell survival, apoptosis, and autophagy. GIMAP8. specifically, is thought to function in maintaining immune homeostasis, potentially through interactions with intracellular organelles or modulation of signaling pathways. Studies suggest its involvement in T-cell development and survival, though its precise mechanisms remain less defined compared to other family members like GIMAP5 or GIMAP7.
Antibodies targeting GIMAP8 are critical tools for elucidating its biological functions. They enable detection and localization of the protein in tissues or cultured cells via techniques such as Western blotting, immunohistochemistry, or flow cytometry. Such antibodies have been employed in research exploring immune disorders, including autoimmune diseases and lymphopenia, as well as cancer immunology, where dysregulated lymphocyte survival pathways may contribute to pathogenesis. Commercial GIMAP8 antibodies are typically raised against specific epitopes, often as monoclonal or polyclonal versions validated for cross-reactivity and specificity. Recent investigations highlight GIMAP8's potential role in metabolic stress responses, linking it to broader cellular adaptation mechanisms, which underscores the growing interest in developing reliable antibodies for both basic and translational studies.
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