| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Purified recombinant fragment of human SCAMP5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SCAMP5抗体的3篇参考文献及摘要概括：
1. **文献名称**：SCAMP5 regulates synaptic vesicle exocytosis by modulating SNARE complex assembly
**作者**：Lin P, Wang C, et al.
**摘要**：该研究利用特异性SCAMP5抗体，通过免疫共沉淀和Western blot技术，揭示了SCAMP5通过与SNARE蛋白相互作用调控突触囊泡释放的分子机制，并发现其在神经退行性疾病中的潜在作用。
2. **文献名称**：Antibody-based profiling of SCAMP5 reveals its overexpression in glioblastoma
**作者**：Zhang Y, Li H, et al.
**摘要**：研究团队开发了高特异性SCAMP5单克隆抗体，用于免疫组织化学分析。结果显示，SCAMP5在胶质母细胞瘤中显著高表达，且与患者预后不良相关，提示其作为癌症治疗靶点的可能性。
3. **文献名称**：SCAMP5 deficiency disrupts autophagosome-lysosome fusion via antibody-guided subcellular localization
**作者**：Saito M, Tanaka K, et al.
**摘要**：通过SCAMP5抗体的亚细胞定位研究，发现SCAMP5缺失会导致自噬体-溶酶体融合障碍，并利用CRISPR/Cas9模型证实其在维持神经元自噬稳态中的关键作用，为相关神经疾病提供机制解释。
(注：以上文献信息为模拟示例，实际引用需查询具体数据库。)
The SCAMP5 (Secretory Carrier Membrane Protein 5) antibody is a tool used to study the SCAMP5 protein, a member of the SCAMP family involved in membrane trafficking and secretory pathways. SCAMPs are integral membrane proteins conserved across eukaryotes, playing roles in vesicle formation, fusion, and cargo sorting. SCAMP5. specifically, is enriched in neuronal and endocrine tissues, suggesting its importance in synaptic vesicle dynamics, neurosecretion, and neurotransmitter release. Research links SCAMP5 to neurological disorders; for example, altered SCAMP5 expression or mutations have been associated with autism spectrum disorders and schizophrenia, highlighting its potential role in synaptic plasticity and neural connectivity.
The SCAMP5 antibody is typically developed using immunogenic peptides or recombinant protein fragments to ensure specificity. It is widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect SCAMP5 expression, localization, and interactions in cellular and tissue samples. Validation often includes knockout cell lines or siRNA knockdown to confirm target specificity. Recent studies also explore SCAMP5's involvement in cancer progression, particularly in regulating exosome secretion and tumor microenvironment communication. Commercial SCAMP5 antibodies are available from various suppliers, with applications spanning basic research to clinical investigations, aiding in elucidating its molecular mechanisms and therapeutic potential.
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