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Mouse Monoclonal IRF5 Antibody

  • 中文名: IRF5抗体
  • 别    名: nan
货号: IPDX15098
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human IRF5
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于IRF5抗体的3篇参考文献及其摘要的简要整理(注:文献信息为模拟示例,建议通过学术数据库核实准确性):

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1. **文献名称**: *"Monoclonal Antibodies Targeting IRF5 Inhibit Inflammatory Pathways in Systemic Lupus Erythematosus"*

**作者**: Tiefenthaler M, et al. (2015)

**摘要**: 本研究开发了靶向IRF5的单克隆抗体,通过阻断其与DNA结合域的作用,显著抑制了狼疮模型小鼠的炎症因子(如IFN-α、IL-6)释放,为SLE治疗提供了潜在策略。

2. **文献名称**: *"IRF5 Antibody-Based Therapy Suppresses Tumor Growth in Melanoma Models"*

**作者**: Barnes BJ, et al. (2016)

**摘要**: 研究利用抗IRF5抗体干预黑色素瘤微环境,发现其能促进肿瘤细胞凋亡并增强PD-1抑制剂疗效,揭示了IRF5抗体在癌症免疫联合治疗中的应用前景。

3. **文献名称**: *"Anti-IRF5 Antibodies Attenuate Macrophage Polarization in Rheumatoid Arthritis"*

**作者**: Orozco G, et al. (2010)

**摘要**: 通过阻断IRF5活性,抗IRF5抗体减少了类风湿关节炎患者巨噬细胞向促炎表型(M1)的极化,降低了关节炎症和骨质破坏,提示其作为RA生物制剂的潜力。

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建议通过 **PubMed/Google Scholar** 检索实际文献,使用关键词如 **"IRF5 antibody therapeutic"** 或 **"IRF5 inhibitor"** 获取最新研究。

背景信息

The IRF5 (Interferon Regulatory Factor 5) antibody is a key tool for studying the role of IRF5. a transcription factor in the interferon (IFN) regulatory factor family. IRF5 is critical in innate and adaptive immune responses, primarily regulating the expression of type I IFNs and pro-inflammatory cytokines (e.g., TNF-α, IL-6. IL-12). It is activated by pattern recognition receptors (PRRs) like TLRs and influences immune cell differentiation, particularly in macrophages and B cells. Dysregulation of IRF5 is linked to autoimmune diseases (e.g., systemic lupus erythematosus, rheumatoid arthritis) and cancers, where it may drive chronic inflammation or tumor progression. IRF5 antibodies are widely used in research to detect IRF5 expression, localization, and post-translational modifications via techniques like Western blotting, immunohistochemistry, and flow cytometry. They also aid in mechanistic studies, such as identifying IRF5’s interaction partners or its role in signaling pathways (e.g., TLR/MyD88). Clinically, IRF5 antibodies have potential diagnostic value for autoimmune disorders and may guide therapeutic strategies targeting IRF5 activity. However, challenges remain in standardizing antibody specificity across experimental models and human tissues.

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