| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PADI2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于PADI2抗体的3篇参考文献示例(注：文献信息为模拟，实际引用需核实)：
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1. **文献名称**：*"Autoantibodies against PADI2 in Rheumatoid Arthritis: A Novel Diagnostic Biomarker"*
**作者**：Zhang Y, et al.
**摘要**：本研究通过ELISA检测类风湿性关节炎(RA)患者血清中的抗PADI2自身抗体，发现其阳性率显著高于健康对照组，提示抗PADI2抗体可能作为RA的新型诊断标志物，并可能与疾病活动度相关。
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2. **文献名称**：*"PADI2-Mediated Citrullination in Tumor-Associated Macrophages Promotes Immune Suppression"*
**作者**：Smith JL, et al.
**摘要**：利用抗PADI2抗体进行免疫组化分析，揭示肿瘤微环境中PADI2高表达于巨噬细胞，其介导的蛋白瓜氨酸化通过调控趋化因子分泌促进免疫抑制，为靶向PADI2的癌症治疗提供依据。
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3. **文献名称**：*"Development of a Monoclonal Antibody Specific for Human PADI2 and Its Application in Multiple Sclerosis Research"*
**作者**：Wang H, et al.
**摘要**：研究团队开发了一种高特异性抗人PADI2单克隆抗体，通过Western blot和免疫荧光验证其在多发性硬化症(MS)患者脑组织中的表达定位，发现PADI2在脱髓鞘区域的异常激活可能与疾病进展相关。
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**备注**：以上文献为示例性内容，实际研究中需通过PubMed、Web of Science等平台以关键词“PADI2 antibody”、“anti-PADI2 autoantibody”或“PADI2 citrullination”检索最新文献。
**Background of PADI2 Antibodies**
PADI2 (peptidyl arginine deiminase 2) is a calcium-dependent enzyme belonging to the peptidyl arginine deiminase family, which catalyzes the post-translational conversion of arginine residues to citrulline in proteins. This process, termed citrullination, plays critical roles in epigenetic regulation, protein function, and cellular signaling. PADI2 is widely expressed in various tissues, including the brain, immune cells, and reproductive organs, and is implicated in physiological processes like myelination and chromatin remodeling, as well as pathologies such as cancer, autoimmune diseases (e.g., rheumatoid arthritis), and neurodegenerative disorders.
PADI2 antibodies are essential tools for detecting and studying the expression, localization, and activity of PADI2 in research. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore its role in disease mechanisms or normal biology. For example, PADI2-specific antibodies have been used to investigate its involvement in citrullinating histones (affecting gene expression) or myelin basic protein (linked to multiple sclerosis). Commercial PADI2 antibodies are typically raised against unique epitopes of human PADI2. though cross-reactivity with orthologs in model organisms (e.g., mice) is often validated. Challenges include ensuring specificity due to homology among PADI family members (PADI1-4. PADI6). Recent studies also highlight PADI2's potential as a therapeutic target, driving demand for reliable antibodies to support drug development and biomarker discovery.
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