| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human UGDH |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于UGDH(UDP-glucose 6-dehydrogenase)抗体的参考文献示例(注：内容为示例性概括，具体文献需根据实际数据库查询)：
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1. **文献名称**: *"UGDH promotes tumor progression by modulating hyaluronan synthesis in the tumor microenvironment"*
**作者**: Smith J, et al.
**摘要**: 本研究探讨了UGDH在肿瘤微环境中通过调控透明质酸(HA)合成促进肿瘤侵袭的机制。通过免疫组化和Western blot技术使用UGDH抗体，发现高表达UGDH的癌细胞通过HA介导的细胞外基质重塑增强转移能力，提示UGDH作为潜在治疗靶点。
2. **文献名称**: *"Role of UGDH in hepatic stellate cell activation and liver fibrosis"*
**作者**: Zhang L, et al.
**摘要**: 研究利用UGDH特异性抗体分析UGDH在肝纤维化中的作用，发现UGDH在活化的肝星状细胞中表达显著上调，并通过调节糖胺聚糖代谢促进纤维化进程。抑制UGDH可减少胶原沉积，为抗纤维化治疗提供新思路。
3. **文献名称**: *"UGDH as a prognostic biomarker in triple-negative breast cancer"*
**作者**: Kim S, et al.
**摘要**: 通过免疫荧光和流式细胞术结合UGDH抗体，研究揭示了UGDH在三阴性乳腺癌中的高表达与患者预后不良相关。UGDH通过影响糖代谢重编程促进肿瘤耐药性，提示其作为预后标志物的潜力。
4. **文献名称**: *"Development of a monoclonal antibody against UGDH for functional studies in ovarian cancer"*
**作者**: Patel R, et al.
**摘要**: 本研究报道了一种高特异性抗UGDH单克隆抗体的开发，并验证其在卵巢癌细胞系中的功能应用。实验表明，阻断UGDH活性可抑制细胞迁移和血管生成，支持UGDH在癌症进展中的关键作用。
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**提示**：以上文献信息为示例，实际引用请通过PubMed、Web of Science等数据库查询真实文献，并核对作者、标题及摘要准确性。
The UDP-glucose dehydrogenase (UGDH) antibody is a crucial tool for studying the enzyme UGDH, which plays a pivotal role in carbohydrate metabolism. UGDH catalyzes the NAD+-dependent oxidation of UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key precursor for synthesizing glycosaminoglycans (GAGs), hyaluronic acid, and other extracellular matrix components. These molecules are essential for cell signaling, tissue structure, and cellular interactions, implicating UGDH in processes like development, wound healing, and disease pathogenesis, including cancer metastasis and fibrosis.
UGDH antibodies are widely used to detect and quantify UGDH protein levels in various experimental models, such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers utilize these antibodies to investigate UGDH's expression patterns across tissues or its dysregulation in diseases. For instance, elevated UGDH levels in certain cancers correlate with increased invasiveness and poor prognosis, highlighting its potential as a therapeutic target. Additionally, UGDH antibodies aid in studying post-translational modifications or interactions with regulatory proteins.
Commercial UGDH antibodies are typically raised in hosts like rabbits or mice, with validation in specific applications and species. Their specificity is confirmed using knockout controls or siRNA-mediated silencing. By enabling precise localization and quantification of UGDH, these antibodies advance our understanding of its biological roles and its relevance in human health and disease.
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