| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PSF2; Pfs2; HSPC037 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human GINS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GINS2抗体的3篇参考文献的概括(注：文献信息为模拟示例，实际引用需核实原始文献)：
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1. **文献名称**: "GINS2 Maintains the Stemness of Human Colorectal Cancer Cells via UHRF1-Mediated Epigenetic Regulation"
**作者**: Li Y, et al.
**摘要**: 研究利用GINS2特异性抗体，通过免疫共沉淀和ChIP实验，揭示了GINS2通过调控UHRF1的表观遗传修饰维持结直肠癌干细胞的自我更新能力，提示其作为潜在治疗靶点。
2. **文献名称**: "Prognostic Significance of GINS2 Expression and Its Interaction with CDK1 in Hepatocellular Carcinoma"
**作者**: Wang X, et al.
**摘要**: 通过免疫组化(使用GINS2抗体)分析肝癌组织样本，发现GINS2高表达与患者不良预后相关，并证实其与CDK1的相互作用促进肝癌细胞周期进展和转移。
3. **文献名称**: "Development of a High-Specificity Monoclonal Antibody for GINS2 and Its Application in Early Cancer Diagnosis"
**作者**: Chen R, et al.
**摘要**: 报道了一种新型GINS2单克隆抗体的制备及验证，该抗体在ELISA和免疫荧光中表现出高灵敏度和特异性，可应用于血液样本中GINS2的早期癌症标志物检测。
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**说明**：以上文献信息为示例，实际研究中需通过PubMed、Web of Science等平台检索真实文献(关键词：GINS2 antibody, cancer, biomarker)。若需具体文献协助，可提供更详细的研究背景进一步筛选。
The GINS2 antibody targets the GINS complex subunit 2 (GINS2), a critical component of the GINS complex, which plays a central role in DNA replication and cell cycle progression. The GINS complex, composed of SLD5. PSF1 (GINS1), PSF2 (GINS2), and PSF3 (GINS3), is essential for the initiation and elongation phases of DNA replication by stabilizing the interaction between the minichromosome maintenance (MCM) helicase and DNA polymerase. GINS2. encoded by the *PSF2* gene, is particularly important for maintaining the structural integrity of the complex and ensuring proper replication fork progression.
Antibodies against GINS2 are widely used in molecular and cellular biology research to study DNA replication mechanisms, cell cycle regulation, and genome stability. They enable detection of GINS2 expression levels via techniques like Western blotting, immunofluorescence, and immunohistochemistry, helping to elucidate its role in normal cellular processes and diseases such as cancer. Dysregulation of GINS2 has been linked to tumorigenesis, making it a potential biomarker or therapeutic target. Researchers also use GINS2 antibodies in co-immunoprecipitation assays to investigate interactions within the GINS complex or with other replication machinery components. Specificity and validation (e.g., knockout/knockdown controls) are critical to ensure reliable results. These antibodies are typically raised in hosts like rabbits or mice and are applicable to human, mouse, or rat samples, depending on epitope conservation.
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