| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HR6B; UBC2; HHR6B; RAD6B; E2-17kDa |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human UBE2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UBE2B抗体的示例参考文献(内容为虚构示例，供格式参考)：
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1. **"UBE2B regulates DNA repair through ubiquitination of replication protein A"**
*Authors: Smith A, Lee B, et al. (2020)*
**摘要**: 本研究利用UBE2B特异性抗体，通过免疫共沉淀和Western blot技术，揭示了UBE2B通过泛素化修饰复制蛋白A(RPA)调控DNA同源重组修复的分子机制。
2. **"UBE2B deficiency and male infertility: A role in spermatogenesis"**
*Authors: Chen X, Wang Y, et al. (2018)*
**摘要**: 通过UBE2B抗体检测小鼠睾丸组织中的蛋白表达，发现UBE2B缺失导致精子发生异常，表明其在生殖细胞分化中起关键作用，并与人类非梗阻性无精症相关。
3. **"UBE2B-mediated protein degradation in neurodegenerative disease models"**
*Authors: Gupta R, Müller S, et al. (2021)*
**摘要**: 研究使用UBE2B抗体分析阿尔茨海默病模型中的泛素化水平，发现UBE2B异常表达导致Tau蛋白降解受阻，提示其与神经退行性病变的潜在关联。
4. **"Development and validation of a high-affinity monoclonal antibody for UBE2B"**
*Authors: Tanaka K, Park J, et al. (2019)*
**摘要**: 报道了一种新型UBE2B单克隆抗体的开发与验证，该抗体在免疫组化、流式细胞术中表现出高特异性，为UBE2B的临床病理研究提供了可靠工具。
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**注**：以上文献信息为模拟示例，实际引用需通过学术数据库(如PubMed、Web of Science)检索真实发表的研究。如需具体文献，建议以“UBE2B antibody”为关键词进行专业检索。
The UBE2B antibody targets the ubiquitin-conjugating enzyme E2B (UBE2B), a key component of the ubiquitin-proteasome system involved in protein degradation and post-translational modification. UBE2B, also known as RAD6B, plays a critical role in DNA repair, particularly in error-free DNA damage tolerance via its interaction with RAD18. It facilitates the transfer of ubiquitin to substrate proteins, marking them for proteasomal degradation or modulating their function. UBE2B is essential in spermatogenesis, as studies link its dysfunction to male infertility due to impaired histone-to-protamine transition during sperm maturation.
UBE2B antibodies are widely used in research to study protein expression, localization, and interactions in cellular processes like DNA repair, cell cycle regulation, and epigenetic modulation. They are employed in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation. Dysregulation of UBE2B has been implicated in cancers (e.g., prostate, breast) and neurodegenerative disorders, making these antibodies valuable for exploring disease mechanisms. Additionally, UBE2B's role in maintaining genomic stability highlights its potential as a therapeutic target. Researchers rely on high-specificity UBE2B antibodies to dissect its molecular pathways and validate its involvement in cellular stress responses and developmental biology.
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