| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | KOX32 |
| WB Predicted band size | 64 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ZNF34 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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关于ZNF34抗体的研究文献较少，以下为模拟示例(可能无真实对应文献，建议通过PubMed或Google Scholar检索验证)：
1. **标题**: *Characterization of ZNF34 antibody for chromatin immunoprecipitation in human cells*
**作者**: Smith A et al.
**摘要**: 开发并验证了一种兔源多克隆ZNF34抗体，用于ChIP-seq分析，证明其在人肝癌细胞中能特异性识别ZNF34蛋白的C端结构域。
2. **标题**: *ZNF34 expression profiling in neural tissues using a novel monoclonal antibody*
**作者**: Chen L et al.
**摘要**: 报道了一种小鼠单克隆抗体(克隆号：3B8)，通过免疫组化验证其在脑组织中的特异性，发现ZNF34在小鼠海马神经元高表达。
3. **标题**: *Functional study of ZNF34 knockout via CRISPR/Cas9 validated by specific antibody*
**作者**: Gupta R et al.
**摘要**: 使用商业抗体验证ZNF34基因敲除模型(货号：AB123)，Western blot显示该抗体能有效区分野生型与敲除型细胞系。
**注意**：以上为假设性示例，实际文献需通过学术数据库检索。建议：
1. 在**PubMed**搜索“ZNF34 antibody”或“anti-ZNF34”
2. 查看抗体公司(如Abcam、Santa Cruz)的产品说明书引用文献
3. 关注锌指蛋白家族综述中提到的相关抗体研究。
The ZNF34 antibody is a research tool designed to detect zinc finger protein 34 (ZNF34), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (ZNF) family. ZNF34 is characterized by multiple C2H2-type zinc finger motifs, which facilitate DNA binding, and a KRAB domain implicated in transcriptional repression via interaction with co-repressors. While the precise biological role of ZNF34 remains under investigation, it is hypothesized to participate in gene regulation, chromatin remodeling, and cellular differentiation processes. Dysregulation of ZNF proteins, including ZNF34. has been linked to cancers, neurological disorders, and developmental abnormalities.
ZNF34 antibodies are typically produced in immunized hosts (e.g., rabbits or mice) using recombinant ZNF34 protein fragments or synthetic peptides as antigens. These antibodies enable the identification and localization of ZNF34 in experimental applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes testing for specificity against target epitopes and cross-reactivity assessments with related ZNF family members.
Research utilizing ZNF34 antibodies aims to elucidate its expression patterns, post-translational modifications, and interactions with nucleic acids or proteins. Emerging studies suggest potential roles in cellular stress responses and tumorigenesis, positioning ZNF34 as a candidate biomarker or therapeutic target. However, functional studies remain limited, highlighting the need for further characterization of its molecular mechanisms and disease associations.
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