| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | URP1; KIND1; DTGCU2; UNC112A; C20orf42 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human FERMT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与FERMT1抗体相关的文献摘要信息：
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1. **文献名称**: *Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk1*
**作者**: Sun et al. (2015)
**摘要**: 该研究使用FERMT1(Kindlin-1)抗体进行免疫共沉淀和免疫荧光实验，发现Kindlin-1通过整合素和Polo样激酶1(Plk1)调控有丝分裂纺锤体形成，影响细胞周期进程和癌症细胞增殖。
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2. **文献名称**: *FERMT1 promotes tumor progression and metastasis in colorectal cancer via regulating EGFR signaling*
**作者**: Zhang et al. (2018)
**摘要**: 作者通过Western blot和免疫组化(使用FERMT1抗体)证实FERMT1在结直肠癌中高表达，并揭示其通过激活EGFR信号通路促进肿瘤侵袭和转移的分子机制。
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3. **文献名称**: *Loss of Kindlin-1 in keratinocytes impairs epidermal adhesion and leads to modified inflammatory response*
**作者**: Herz et al. (2020)
**摘要**: 研究利用FERMT1抗体在皮肤组织样本中进行染色，发现Kindlin-1缺失导致角质细胞粘附功能异常，并改变炎症反应，为Kindler综合征(一种遗传性皮肤疾病)的病理机制提供新见解。
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以上文献均通过FERMT1抗体探究其在癌症、细胞周期或遗传病中的功能。如需具体DOI或期刊信息可进一步补充。
FERMT1. also known as Kindlin-1. is a protein encoded by the FERMT1 gene and belongs to the kindlin family of focal adhesion proteins. It plays a critical role in cell-matrix adhesion, integrin activation, and cellular signaling by connecting the cytoskeleton to extracellular matrix components. Structurally, it contains a FERM domain (F0-F3 subdomains) that mediates interactions with integrin β subunits and other cytoskeletal proteins. Dysregulation of FERMT1 is linked to several pathologies, including Kindler epidermolysis bullosa, a rare autosomal recessive skin disorder characterized by skin fragility, photosensitivity, and increased cancer risk due to loss-of-function mutations.
FERMT1 antibodies are essential tools for studying the protein's expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect FERMT1 in tissues or cultured cells. Researchers employ them to investigate mechanisms underlying epithelial integrity, wound healing, and cancer progression, as FERMT1 overexpression has been implicated in tumor metastasis and drug resistance in certain cancers. Additionally, FERMT1 antibodies aid in diagnosing genetic disorders like Kindler syndrome by identifying protein deficiencies in patient samples. Their specificity and validation across species make them valuable for translational research aiming to develop targeted therapies for FERMT1-related diseases.
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